{"id":"W2940414628","doi":"10.1016/j.mrrev.2019.04.003","title":"Functional genomics applications and therapeutic implications in sarcopenia","year":2019,"lang":"en","type":"review","venue":"Mutation Research/Reviews in Mutation Research","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Héma-Québec","funders":"","keywords":"Sarcopenia; Functional genomics; Genomics; Proteomics; Epigenomics; Computational biology; Biology; Gene silencing; Bioinformatics; Gene; Genome; Gene expression; Genetics; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006642099,0.0003489453,0.0008902206,0.001485995,0.000341629,0.0001113377,0.0005908565,0.0005744343,0.0001431844],"category_scores_gemma":[0.0007636623,0.0003293465,0.0001926492,0.002076052,0.0005513167,0.00002018701,0.0003486764,0.001478279,0.0006826562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002998261,"about_ca_system_score_gemma":0.001289214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008275094,"about_ca_topic_score_gemma":0.0003462544,"domain_scores_codex":[0.9924626,0.003968409,0.001088579,0.001184627,0.0005196705,0.0007760994],"domain_scores_gemma":[0.9973326,0.0009121255,0.0002317898,0.0008589863,0.0005168355,0.0001476028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005086798,0.0001885928,0.00009405252,0.0047111,0.00004533634,0.000003213088,0.0001041868,0.00010614,0.0002845343,0.00254947,0.001515736,0.9903468],"study_design_scores_gemma":[0.0005315297,0.0001623045,0.001562584,0.0008353865,0.00002766277,0.00002137096,0.0001714436,0.00007573091,0.00001116357,0.003957369,0.9923279,0.0003155584],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005493053,0.9906256,0.0006292706,0.0002861868,0.00005492792,0.006547412,0.00005727303,0.000009743132,0.00124034],"genre_scores_gemma":[0.001494375,0.9863774,0.0002363712,0.00008321128,0.000146713,0.008274417,0.002312358,0.00006924353,0.001005883],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9908122,"threshold_uncertainty_score":0.9999158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2900921565427137,"score_gpt":0.501384779603196,"score_spread":0.2112926230604824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}