{"id":"W2940619822","doi":"10.1126/scisignal.aav4663","title":"Differential regulation of Ca <sup>2+</sup> influx by ORAI channels mediates enamel mineralization","year":2019,"lang":"en","type":"article","venue":"Science Signaling","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"ORAI1; Enamel paint; Chemistry; Mineralization (soil science); Redox; Cell biology; Metabolism; Biophysics; Function (biology); Biochemistry; STIM1; Biology; Inorganic chemistry; Endoplasmic reticulum; Dentistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003061036,0.0001943562,0.0002883067,0.0002214791,0.0003640731,0.0009787701,0.0003368357,0.0004484565,0.002103153],"category_scores_gemma":[0.000396199,0.0001441728,0.0002977744,0.0002266244,0.0005110864,0.001427724,0.0006344223,0.0006447979,0.0004943235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005832007,"about_ca_system_score_gemma":0.000343958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006399433,"about_ca_topic_score_gemma":0.00159565,"domain_scores_codex":[0.9998031,0.00001764996,0.00001880094,0.00003977055,0.00004676727,0.00007394885],"domain_scores_gemma":[0.9998116,0.00003181753,0.0000410231,0.00002158498,0.00004168096,0.00005236412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004087401,0.00001641676,0.0006306216,0.00005147823,0.000004534902,0.00006902767,0.00007606176,0.00004448167,0.9956779,0.001545581,0.0001080895,0.001367082],"study_design_scores_gemma":[0.00011013,0.0001971966,0.03355858,0.00002241337,0.00002959064,0.0003547687,0.0004666307,0.003334926,0.954018,0.002202736,0.005675977,0.00002905663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866143,0.00197184,0.005487031,0.0005108616,0.00007927077,0.00003587009,0.0004993329,0.0001092318,0.004692197],"genre_scores_gemma":[0.9953763,0.0006991814,0.001702922,0.00009740594,0.00001836746,0.00003075699,0.000216677,0.00002788123,0.001830477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002103153,"threshold_uncertainty_score":0.007035732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00613208471468694,"score_gpt":0.2283099383733429,"score_spread":0.2221778536586559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}