{"id":"W2940619822","doi":"10.1126/scisignal.aav4663","title":"Differential regulation of Ca <sup>2+</sup> influx by ORAI channels mediates enamel mineralization","year":2019,"lang":"en","type":"article","venue":"Science Signaling","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"ORAI1; Enamel paint; Chemistry; Mineralization (soil science); Redox; Cell biology; Metabolism; Biophysics; Function (biology); Biochemistry; STIM1; Biology; Inorganic chemistry; Endoplasmic reticulum; Dentistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002486127,0.0001017566,0.0001249674,0.00008039429,0.00007408541,0.00002620997,0.0002144604,0.00009846745,0.0002426995],"category_scores_gemma":[0.00009267203,0.00008807403,0.00004395328,0.0002121323,0.0001994071,0.00001304726,0.00008643293,0.0000414327,0.00001021064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001099752,"about_ca_system_score_gemma":0.0000813549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004679096,"about_ca_topic_score_gemma":0.000002760946,"domain_scores_codex":[0.9990336,0.00003562879,0.0001991769,0.0003294822,0.0001774835,0.0002246115],"domain_scores_gemma":[0.9994693,0.00001337247,0.0001035192,0.000204393,0.0001556097,0.00005374578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000186473,0.0000162088,0.002063002,0.000009850718,0.000006132004,6.636026e-8,0.0001862056,0.005422204,0.9914918,0.0001032127,0.0001970789,0.0004855755],"study_design_scores_gemma":[0.0003243923,0.0001965555,0.0005590165,0.00001716829,0.000007132298,0.000001809319,0.0001477369,0.0232833,0.9738721,0.0001253364,0.001323056,0.0001424373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972317,0.0001130154,0.002043025,0.00006661889,0.0001749901,0.0001309289,0.00001466151,0.000006814479,0.0002183057],"genre_scores_gemma":[0.9989954,0.00001454992,0.0001397247,0.00008589309,0.0001423851,0.000004327159,0.000177485,0.000007588067,0.0004326021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01786109,"threshold_uncertainty_score":0.3591555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00613208471468694,"score_gpt":0.2283099383733429,"score_spread":0.2221778536586559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}