{"id":"W2940643850","doi":"10.1016/j.jpsychires.2019.04.027","title":"Response to: Goldberg et al. and Severance et al. Letters to the Editor: The clinical significance of improving remission over standard of care – The reality of treatment resistant-based therapies","year":2019,"lang":"en","type":"letter","venue":"Journal of Psychiatric Research","topic":"Treatment of Major Depression","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine in St. Louis; Janssen Biotech; Canadian Institutes of Health Research; National Institutes of Health; Allergan; Alkermes; Rogers Family Foundation; Assurex Health; National Institute of Mental Health; Pfizer; Ontario Brain Institute; Foundation for Barnes-Jewish Hospital; Agency for Healthcare Research and Quality; Stanley Medical Research Institute; Biogen","keywords":"Severance; Standard of care; Psychology; Psychotherapist; Medicine; Internal medicine; Political science; Law","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0139028,0.0003699696,0.001193416,0.0004876641,0.0001804924,0.00005243692,0.0008406761,0.0002851003,0.00002286137],"category_scores_gemma":[0.001796738,0.0001558425,0.0005749111,0.0006662359,0.0004105409,0.00006939484,0.0001633778,0.002554031,0.000001324324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000531912,"about_ca_system_score_gemma":0.002445261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004671059,"about_ca_topic_score_gemma":0.00006419205,"domain_scores_codex":[0.9879662,0.005910643,0.001633274,0.0005329161,0.003501184,0.0004557717],"domain_scores_gemma":[0.9863837,0.008962636,0.001537037,0.001690266,0.001272031,0.0001543439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.04686496,0.0001603774,0.00510697,0.0003706376,0.0003272353,0.00004032097,0.00100316,0.00006355331,0.0141054,0.000002134195,0.9294483,0.002506918],"study_design_scores_gemma":[0.004375075,0.01274756,0.04330601,0.001676157,0.0002762327,0.00001671427,0.0005937768,0.000007874566,0.001418819,0.00001648688,0.9354135,0.0001517852],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1706123,0.004541152,0.00007482003,0.8211169,0.001414528,0.001907105,0.0002642976,0.000005422436,0.00006352219],"genre_scores_gemma":[0.4126137,0.008568934,0.005217187,0.563923,0.00791932,0.0001365215,0.00004028561,0.0002535435,0.001327509],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2571939,"threshold_uncertainty_score":0.9997471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05641146574841558,"score_gpt":0.428866787364396,"score_spread":0.3724553216159804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}