{"id":"W2940661744","doi":"10.1016/j.resp.2019.04.013","title":"Intranasal instillation of distilled water, hypertonic saline and sodium bicarbonate promotes redox imbalance and acute lung inflammation in adult mice","year":2019,"lang":"en","type":"article","venue":"Respiratory Physiology & Neurobiology","topic":"Hydrogen's biological and therapeutic effects","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; University of Toronto; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Hypertonic saline; Nasal administration; Saline; Sodium bicarbonate; Superoxide dismutase; Inflammation; Oxidative stress; Medicine; Lung; Pharmacology; Chemistry; Endocrinology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001822384,0.0002104338,0.0006163018,0.0001200061,0.00002996354,0.00000299868,0.00007085587,0.000283991,0.00001502001],"category_scores_gemma":[0.00004903348,0.0001353811,0.00004668767,0.000112882,0.0003228963,0.00004952802,0.00008463224,0.0002532329,0.000007360247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001750668,"about_ca_system_score_gemma":0.00002972204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008918158,"about_ca_topic_score_gemma":0.000006446776,"domain_scores_codex":[0.9984241,0.0003461409,0.0004090693,0.0004692757,0.00004842267,0.0003029736],"domain_scores_gemma":[0.9993495,0.0001792019,0.000130334,0.0002017166,0.00007332573,0.00006585886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001193453,0.00005005562,0.05588347,0.0001569788,0.00007050751,0.000009314632,0.00008152035,0.000007742758,0.9415196,0.000250422,0.000001404445,0.0007755185],"study_design_scores_gemma":[0.005738578,0.003226525,0.6046267,0.000117842,0.000122297,0.00007211905,0.00001219565,0.00325325,0.3813378,0.0004838652,0.0007186438,0.0002901561],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982088,0.0004106483,0.000002518636,0.0005045848,0.0001222317,0.0006404216,0.000008867354,0.00003755803,0.00006435456],"genre_scores_gemma":[0.9987796,0.0002668804,0.00002741373,0.0007450551,0.00006958427,0.00002285807,0.0000604713,0.0000146765,0.00001343923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5601818,"threshold_uncertainty_score":0.5520683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006276775279166556,"score_gpt":0.2389792584673861,"score_spread":0.2327024831882195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}