{"id":"W2940776419","doi":"10.3390/polym11040745","title":"Polymeric Nanoparticles in Gene Therapy: New Avenues of Design and Optimization for Delivery Applications","year":2019,"lang":"en","type":"review","venue":"Polymers","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":340,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; University of Saskatchewan","keywords":"Gene delivery; Nanotechnology; Polymer; Immunogenicity; Transfection; Smart polymer; Genetic enhancement; Materials science; Drug delivery; Viral vector; Chemistry; Gene; Biology; Biochemistry; Immune system; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006096363,0.0001541686,0.0003623228,0.0000797597,0.00001776967,0.00000954656,0.0001290229,0.0001245266,0.000008787484],"category_scores_gemma":[0.000006845685,0.0001410979,0.0001141113,0.00009217863,0.00003569805,0.000003258738,0.00003062344,0.00003251282,0.000002133524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007270987,"about_ca_system_score_gemma":0.0001913414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004184145,"about_ca_topic_score_gemma":0.000001859448,"domain_scores_codex":[0.9992816,0.00004796644,0.0002433684,0.0002533178,0.00004151717,0.0001322472],"domain_scores_gemma":[0.9995574,0.00003037912,0.0001530981,0.000200426,0.00002154109,0.00003715033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003299677,0.00002136962,0.000004342869,0.0004337533,0.00007249141,1.078109e-7,0.00001678132,0.0002547343,0.01513902,0.000003348403,0.0000963168,0.9839247],"study_design_scores_gemma":[0.001179933,0.0007973214,0.000005275411,0.001283313,0.0004618843,0.00001712828,0.00004751911,0.0005419527,0.2215665,0.00002131487,0.7732829,0.0007949683],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004670164,0.9746639,0.02402069,0.000006790845,0.00004059924,0.0007506774,0.00003547313,0.000003034022,0.00001180679],"genre_scores_gemma":[0.0005193316,0.9959546,0.002824833,0.0000334634,0.00007363728,0.0001698962,0.0001852942,0.00002574905,0.0002132207],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9831298,"threshold_uncertainty_score":0.5753806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0558000366586324,"score_gpt":0.3101213973876028,"score_spread":0.2543213607289704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}