{"id":"W2940776419","doi":"10.3390/polym11040745","title":"Polymeric Nanoparticles in Gene Therapy: New Avenues of Design and Optimization for Delivery Applications","year":2019,"lang":"en","type":"review","venue":"Polymers","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":340,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; University of Saskatchewan","keywords":"Gene delivery; Nanotechnology; Polymer; Immunogenicity; Transfection; Smart polymer; Genetic enhancement; Materials science; Drug delivery; Viral vector; Chemistry; Gene; Biology; Biochemistry; Immune system; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001402226,0.0006773579,0.001138475,0.0009628659,0.000311453,0.001397659,0.0008678156,0.001442948,0.002745774],"category_scores_gemma":[0.0008379095,0.0004091665,0.0007566848,0.0008571514,0.001301322,0.002456802,0.0008563342,0.002448166,0.00146093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001205546,"about_ca_system_score_gemma":0.0006412721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005080267,"about_ca_topic_score_gemma":0.0005141505,"domain_scores_codex":[0.9993913,0.0001489385,0.00003091694,0.0001599588,0.0002089607,0.00005981049],"domain_scores_gemma":[0.9996448,0.0001463982,0.00005200986,0.00003251759,0.00008752888,0.00003680673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002588964,0.0005916309,0.0009069066,0.004566233,0.0001235344,0.0004248211,0.0004928049,0.01074345,0.2007614,0.1605731,0.01566986,0.6048874],"study_design_scores_gemma":[0.0001007458,0.001331603,0.0009066062,0.0009218316,0.0001143963,0.000923319,0.0001940779,0.01723794,0.0855853,0.05832243,0.8342237,0.0001379743],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01981701,0.7976499,0.1478143,0.008076878,0.001178298,0.000191884,0.0001384187,0.0003403499,0.02479299],"genre_scores_gemma":[0.1352727,0.7294017,0.113088,0.003674268,0.001354594,0.0005496518,0.0002345335,0.0001780343,0.01624654],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002745774,"threshold_uncertainty_score":0.009185553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0558000366586324,"score_gpt":0.3101213973876028,"score_spread":0.2543213607289704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}