{"id":"W2940780954","doi":"10.1038/s41598-019-43005-z","title":"Discovery of selective activators of PRC2 mutant EED-I363M","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; National Institute on Drug Abuse; Canadian Institutes of Health Research; University of North Carolina at Chapel Hill; National Institutes of Health; U.S. Department of Health and Human Services; Ontario Genomics; Ontario Ministry of Research, Innovation and Science; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Wellcome Trust; Pfizer; National Institute of General Medical Sciences; Kwanjeong Educational Foundation; Novartis Pharma; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA","keywords":"PRC2; Allosteric regulation; Mutant; Mutation; EZH2; Histone; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001621602,0.0003141647,0.000362156,0.0001058059,0.0001799304,0.0002825737,0.0004432579,0.0002484804,0.00244967],"category_scores_gemma":[0.0002023898,0.0001541916,0.0002705222,0.0001092503,0.0001569217,0.0002052494,0.0003162499,0.0005865112,0.0003704286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004551063,"about_ca_system_score_gemma":0.0004509758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009968954,"about_ca_topic_score_gemma":0.002252664,"domain_scores_codex":[0.9999403,0.000008877139,0.00000224335,0.00001264898,0.0000208082,0.00001506942],"domain_scores_gemma":[0.9999547,0.00001403715,0.00001046612,0.0000029885,0.000006002972,0.00001179129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002302442,0.001057038,0.004031285,0.001396831,0.0002621615,0.001074983,0.0001630501,0.276132,0.6188332,0.02372798,0.006725905,0.06429297],"study_design_scores_gemma":[0.001025003,0.003765995,0.001334609,0.00007277118,0.0001810427,0.0004500096,0.0001718563,0.4392527,0.5254936,0.003473651,0.02469909,0.00007969319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663405,0.002884655,0.01743125,0.0006202987,0.00009275673,0.0001039186,0.0005262128,0.0003938072,0.0116066],"genre_scores_gemma":[0.9869523,0.001115312,0.009383617,0.0001395702,0.000008370208,0.00009108397,0.0003374126,0.00005502847,0.001917261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00244967,"threshold_uncertainty_score":0.008194923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005776661467612348,"score_gpt":0.2374123083128795,"score_spread":0.2316356468452672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}