{"id":"W2940860336","doi":"10.1093/rheumatology/kez123","title":"Autoantibodies to a novel Rpp38 (Th/To) derived B-cell epitope are specific for systemic sclerosis and associate with a distinct clinical phenotype","year":2019,"lang":"en","type":"article","venue":"Lara D. Veeken","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Centre Hospitalier de l’Université de Montréal","funders":"University of Calgary","keywords":"Autoantibody; Medicine; Epitope; Phenotype; Clinical phenotype; Immunology; B cell; Multiple sclerosis; Systemic disease; Antibody; Immunopathology; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002839435,0.000394466,0.0002596705,0.0004590096,0.0001719394,0.0001820355,0.0001899904,0.000248877,0.003924613],"category_scores_gemma":[0.0004093637,0.00009108285,0.0001429237,0.0002127433,0.0002340979,0.0001242034,0.0001571729,0.0001891425,0.0004575776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000135379,"about_ca_system_score_gemma":0.00007745024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002093203,"about_ca_topic_score_gemma":0.0002090811,"domain_scores_codex":[0.9998287,0.00002396538,0.00001823325,0.00006444508,0.00004332023,0.00002132627],"domain_scores_gemma":[0.9997044,0.00006039217,0.0001408818,0.00002145007,0.00003345691,0.00003931353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001134375,0.0002239558,0.3399444,0.0002999135,0.0001682407,0.003000498,0.0002070871,0.0001675089,0.6394144,0.000114524,0.0003466736,0.01497853],"study_design_scores_gemma":[0.00009566092,0.001424952,0.9161013,0.00004842278,0.0001357292,0.02724974,0.000122055,0.0005963177,0.05193784,0.0001333001,0.00214638,0.00000822217],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988875,0.0003750782,0.000243643,0.00001083566,0.000002405394,0.000008276933,0.00006138012,0.00001017153,0.0004007308],"genre_scores_gemma":[0.9992434,0.0001277149,0.000285089,0.00001310791,0.00001096849,0.000007496782,0.0001131619,0.000002200091,0.0001969571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003924613,"threshold_uncertainty_score":0.01312912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04461807556429771,"score_gpt":0.2823310015924431,"score_spread":0.2377129260281454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}