{"id":"W2941020419","doi":"10.1093/neuonc/noz036.008","title":"ATRT-09. INTEGRATIVE ANALYSES OF GENE REGULATORY LANDSCAPES REVEAL RHABDOID TUMOR SUBGROUPS WITH POSSIBLE IMMUNE MODULATION THROUGH EPIGENETIC DYSREGULATION","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Tumors and Oncological Cases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"","keywords":"Epigenetics; Immune system; Gene; Immune dysregulation; Biology; Epigenesis; Psychology; DNA methylation; Neuroscience; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002285499,0.0002881598,0.0009782141,0.0001632459,0.00007605956,0.00001133743,0.000132936,0.0001952799,0.0002868202],"category_scores_gemma":[0.0001882811,0.0001923269,0.0001767501,0.0004606521,0.0001902164,0.0001632781,0.00005470611,0.0003094194,0.00003487327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002031536,"about_ca_system_score_gemma":0.0002907344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001109048,"about_ca_topic_score_gemma":0.00006185203,"domain_scores_codex":[0.997849,0.0002827508,0.0006583276,0.0005116417,0.0003634041,0.0003348055],"domain_scores_gemma":[0.9980671,0.000517829,0.0005292576,0.0004690433,0.0003051349,0.0001116101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00204016,0.0003806704,0.05492149,0.00007872277,0.00005380623,0.0002138324,0.000447588,0.001295592,0.9325387,0.0003126672,0.0001761309,0.007540666],"study_design_scores_gemma":[0.003280414,0.01008089,0.6155363,0.0001043864,0.0002991808,0.0005632389,0.0004636885,0.002365248,0.3653677,0.000409378,0.001289657,0.0002399627],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932438,0.0007242989,0.0006617115,0.0005572658,0.0002363925,0.0008182949,0.00001577408,0.00007380382,0.003668692],"genre_scores_gemma":[0.9939708,0.00005600573,0.004918059,0.0004213749,0.0002281728,0.00003428637,0.00009548149,0.00003639083,0.0002394615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.567171,"threshold_uncertainty_score":0.7842864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02843902868688611,"score_gpt":0.3153083811375602,"score_spread":0.2868693524506741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}