{"id":"W2941048054","doi":"10.1172/jci.insight.127623","title":"Biomarkers of endothelial activation/dysfunction distinguish subgroups of Ugandan patients with sepsis and differing mortality risks","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Canadian Institutes of Health Research; National Institute for Health and Care Research; Pfizer; Henry M. Jackson Foundation","keywords":"Sepsis; Medicine; Endothelial dysfunction; Internal medicine; Vascular endothelial growth factor; Immunology; Endothelial activation; Biomarker; Bioinformatics; Endothelium; Biology; VEGF receptors","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004873777,0.000115653,0.0002849743,0.00007519071,0.00002705108,0.000005919869,0.00002370809,0.00004869205,0.00006956159],"category_scores_gemma":[0.00005620212,0.00007815757,0.00005035666,0.0001171569,0.00005198519,0.00006428683,0.00001982892,0.00004717812,0.000001613913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004584667,"about_ca_system_score_gemma":0.00001875762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004900078,"about_ca_topic_score_gemma":0.00002359814,"domain_scores_codex":[0.9992286,0.00002025011,0.0002175204,0.0001902702,0.0002452362,0.00009812704],"domain_scores_gemma":[0.9993528,0.00008476728,0.0001794788,0.0002075088,0.0001212904,0.00005419467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003015237,0.0006250876,0.9930297,0.0001401234,0.0003367668,0.000001043855,0.0002806075,0.000001893212,0.003289487,0.000042007,0.00002563209,0.001926127],"study_design_scores_gemma":[0.003301384,0.000741676,0.9555279,0.0001945365,0.0001788557,5.419145e-7,0.00005783742,0.00002728741,0.03969545,0.00001261266,0.0001900351,0.00007190355],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978419,0.00003135973,0.00002158254,0.00003250955,0.0001010563,0.0004088117,0.00003363801,0.0000149222,0.001514255],"genre_scores_gemma":[0.9996943,0.00001911353,0.0001115004,0.00003251995,0.00002779421,0.00001440183,0.0000582547,0.00001417188,0.0000278774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03750182,"threshold_uncertainty_score":0.3187173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04972476058193831,"score_gpt":0.2953016203700094,"score_spread":0.2455768597880711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}