{"id":"W2941083042","doi":"10.3390/cells8040374","title":"Chronic Hepatitis C Virus Infection Impairs M1 Macrophage Differentiation and Contributes to CD8+ T-Cell Dysfunction","year":2019,"lang":"en","type":"article","venue":"Cells","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Children's Hospital of Eastern Ontario; Ottawa Hospital; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Immunology; CD8; Cytotoxic T cell; CD86; Chronic infection; T cell; Immune system; Biology; Hepatitis C virus; Virus; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000144885,0.0003502747,0.0001995316,0.0002387472,0.0001282551,0.0002054623,0.0001195673,0.0003228521,0.0008034441],"category_scores_gemma":[0.0001174919,0.0001206208,0.0001854836,0.0001095848,0.000167474,0.000146642,0.0002075708,0.0003403148,0.0003577055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001413659,"about_ca_system_score_gemma":0.00013871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003007863,"about_ca_topic_score_gemma":0.0003544036,"domain_scores_codex":[0.9998842,0.00003296727,0.00001401335,0.00001640337,0.00001441003,0.00003791449],"domain_scores_gemma":[0.9999126,0.000009734217,0.00003501387,0.000009137826,0.00001058749,0.00002278959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008611583,0.0001155533,0.01350496,0.0001896035,0.0000171709,0.0004578183,0.00009167637,0.0001154501,0.9771726,0.0001286328,0.0001413204,0.007204235],"study_design_scores_gemma":[0.0001524416,0.00277983,0.5449789,0.000176111,0.0001284688,0.006923727,0.000579088,0.002625561,0.4306814,0.0006275274,0.01031717,0.00002969793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955202,0.002947265,0.0005638395,0.00008383719,0.00001274786,0.00001620025,0.00008854828,0.00002216766,0.0007453282],"genre_scores_gemma":[0.9973856,0.001502586,0.0003013788,0.00006138211,0.00001137668,0.00001903511,0.0001057194,0.000005459446,0.000607466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008034441,"threshold_uncertainty_score":0.002687752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0033695216595985,"score_gpt":0.1960884222228677,"score_spread":0.1927189005632692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}