{"id":"W2941086159","doi":"10.1021/acs.jmedchem.9b00562","title":"A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function","year":2019,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"FP7 People: Marie-Curie Actions; H2020 European Research Council; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Myeloma UK; Ontario Ministry of Research, Innovation and Science; National Institute for Health and Care Research; Cancer Research UK; Novartis Pharma; Canada Foundation for Innovation; Arthritis Research UK; Alzheimer's Research Foundation; Wellcome Trust; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; AbbVie; Takeda Pharmaceutical Company; Janssen Pharmaceuticals; Merck KGaA; Wellcome; Versus Arthritis; Bayer; Pfizer; Boehringer Ingelheim","keywords":"Chemistry; Chromatin; Histone; Cell biology; Biochemistry; Biology; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004394801,0.0001602488,0.0002437321,0.0000356257,0.00002751037,0.00001286019,0.0001784612,0.0002294435,0.00007740303],"category_scores_gemma":[0.0002184673,0.0001410152,0.0001415314,0.0001066469,0.00004748541,0.000006876695,0.00004235608,0.000196489,0.000007215571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008996776,"about_ca_system_score_gemma":0.0002887124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001699179,"about_ca_topic_score_gemma":7.217973e-7,"domain_scores_codex":[0.9987587,0.00001790298,0.0004611575,0.0002298776,0.0003195153,0.0002128816],"domain_scores_gemma":[0.9989493,0.00001045511,0.0003624238,0.0002097732,0.0002503434,0.0002177075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008515434,0.00003887266,0.0001037089,0.0002095167,0.00007428922,0.00000192668,0.00003689759,0.00007596525,0.9930266,0.000004811362,0.003398301,0.002177527],"study_design_scores_gemma":[0.001869331,0.0006866141,0.0002068174,0.0003181374,0.00004956828,0.0001649472,0.00008360219,0.00005507999,0.9690784,0.000262006,0.02706572,0.0001597645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920919,0.0004240089,0.005398512,0.001177538,0.0002179457,0.0004726604,0.000005546195,0.000006306788,0.0002055935],"genre_scores_gemma":[0.9911329,0.000006139597,0.005731999,0.0002240058,0.001938655,0.00003529297,0.00004008276,0.00002848084,0.0008624378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02394823,"threshold_uncertainty_score":0.5750431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005247602686986676,"score_gpt":0.2330204899231275,"score_spread":0.2277728872361408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}