{"id":"W2941086159","doi":"10.1021/acs.jmedchem.9b00562","title":"A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function","year":2019,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"FP7 People: Marie-Curie Actions; H2020 European Research Council; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Myeloma UK; Ontario Ministry of Research, Innovation and Science; National Institute for Health and Care Research; Cancer Research UK; Novartis Pharma; Canada Foundation for Innovation; Arthritis Research UK; Alzheimer's Research Foundation; Wellcome Trust; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; AbbVie; Takeda Pharmaceutical Company; Janssen Pharmaceuticals; Merck KGaA; Wellcome; Versus Arthritis; Bayer; Pfizer; Boehringer Ingelheim","keywords":"Chemistry; Chromatin; Histone; Cell biology; Biochemistry; Biology; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002183967,0.0003354019,0.0002082076,0.0001921535,0.0002596358,0.0001647731,0.000349664,0.0004858173,0.001919212],"category_scores_gemma":[0.0001634873,0.0001668673,0.0001869367,0.000160432,0.0002046848,0.0001665761,0.0001734173,0.0004817066,0.0002835531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005129669,"about_ca_system_score_gemma":0.0002880671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006991176,"about_ca_topic_score_gemma":0.001298686,"domain_scores_codex":[0.999862,0.00002405575,0.000005632948,0.000037989,0.00003976417,0.00003057044],"domain_scores_gemma":[0.999902,0.00002941919,0.00002207482,0.00001130425,0.00001321963,0.00002201698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005661883,0.00001436063,0.00008709222,0.00002741119,0.000004318087,0.00001415363,0.000005705998,0.00007033122,0.9987184,0.0001187877,0.00004291208,0.0008399013],"study_design_scores_gemma":[0.00001081105,0.0002090082,0.0003816831,0.000001832747,0.000006082396,0.00006195583,0.00000556386,0.0004963114,0.997534,0.00001893892,0.001271365,0.000002370262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674767,0.003451355,0.02250243,0.0003701708,0.00007725277,0.0001427791,0.0005694249,0.0001625651,0.005247385],"genre_scores_gemma":[0.9776909,0.001378771,0.01361228,0.0002008446,0.00001988702,0.0001031014,0.0007822864,0.00002277316,0.006189121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001919212,"threshold_uncertainty_score":0.006420374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005247602686986676,"score_gpt":0.2330204899231275,"score_spread":0.2277728872361408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}