{"id":"W2941130110","doi":"10.1016/j.stemcr.2019.03.011","title":"Ibrutinib Displays Atrial-Specific Toxicity in Human Stem Cell-Derived Cardiomyocytes","year":2019,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of British Columbia; University of Toronto; BC Children's Hospital; Simon Fraser University","funders":"Canadian Institutes of Health Research; Stem Cell Network; St. Paul's Foundation","keywords":"Bruton's tyrosine kinase; Ibrutinib; Tyrosine kinase; Biology; Cardiotoxicity; Induced pluripotent stem cell; Stem cell; Cancer research; Cell; Pharmacology; Signal transduction; Cell biology; Immunology; Leukemia; Biochemistry; Embryonic stem cell; Genetics; Chemotherapy; Chronic lymphocytic leukemia; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001289421,0.0004129547,0.001037536,0.000290457,0.0001129923,0.00007823238,0.0002239995,0.0003211856,0.0005034491],"category_scores_gemma":[0.00001494293,0.0003682671,0.0004601643,0.0005044748,0.0001233492,0.0001400936,0.0002801649,0.000523598,0.0003487394],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007844158,"about_ca_system_score_gemma":0.003047354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000489991,"about_ca_topic_score_gemma":0.00002950373,"domain_scores_codex":[0.9952478,0.0001841266,0.001282274,0.001120054,0.001219294,0.0009464075],"domain_scores_gemma":[0.9969724,0.0002479426,0.000426404,0.001801818,0.000163603,0.0003878479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001100363,0.0006680097,0.08400112,0.002984224,0.0002356264,0.03355355,0.003153059,0.0008130966,0.8590928,0.000113986,0.008982219,0.005301903],"study_design_scores_gemma":[0.02904623,0.0008871534,0.009771833,0.0007035344,0.0001681506,0.003351155,0.002377084,0.0008370365,0.9051274,0.00006505506,0.046515,0.001150351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.930364,0.002145029,0.00001839766,0.00004373505,0.0008016907,0.001906683,0.000006529726,0.0001252408,0.06458873],"genre_scores_gemma":[0.9740503,0.000128233,0.00005792996,0.00003703078,0.0004093355,0.00003616199,0.00005036827,0.00009136356,0.02513926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07422928,"threshold_uncertainty_score":0.9998769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02081744247874157,"score_gpt":0.2731784263610081,"score_spread":0.2523609838822666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}