{"id":"W2941130110","doi":"10.1016/j.stemcr.2019.03.011","title":"Ibrutinib Displays Atrial-Specific Toxicity in Human Stem Cell-Derived Cardiomyocytes","year":2019,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of British Columbia; University of Toronto; BC Children's Hospital; Simon Fraser University","funders":"Canadian Institutes of Health Research; Stem Cell Network; St. Paul's Foundation","keywords":"Bruton's tyrosine kinase; Ibrutinib; Tyrosine kinase; Biology; Cardiotoxicity; Induced pluripotent stem cell; Stem cell; Cancer research; Cell; Pharmacology; Signal transduction; Cell biology; Immunology; Leukemia; Biochemistry; Embryonic stem cell; Genetics; Chemotherapy; Chronic lymphocytic leukemia; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001638726,0.00015727,0.0001663914,0.0001227171,0.0000967478,0.0002108642,0.00009176724,0.0001864329,0.0008290945],"category_scores_gemma":[0.0001092244,0.00005546041,0.0001257558,0.0001258323,0.00009244423,0.00007884683,0.0001197709,0.0002885531,0.0001775535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000130381,"about_ca_system_score_gemma":0.0001222225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006650843,"about_ca_topic_score_gemma":0.0008295379,"domain_scores_codex":[0.9998664,0.00002746079,0.00001868344,0.00001640952,0.00004390578,0.0000272215],"domain_scores_gemma":[0.9999318,0.00002027083,0.0000136968,0.00001171384,0.000009475585,0.00001307328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007492636,0.00002788836,0.0003434331,0.00002212752,0.000005450304,0.00007103932,0.00002219115,0.00009746505,0.9981074,0.00005156188,0.00005373192,0.001122752],"study_design_scores_gemma":[0.00003672771,0.001137671,0.0117739,0.000008305097,0.00002459893,0.0005338167,0.00005606767,0.0009291728,0.9835109,0.00004852673,0.00193601,0.00000437961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945366,0.001204524,0.001735362,0.00007021549,0.00002780019,0.00003197257,0.0003277946,0.00003521379,0.002030524],"genre_scores_gemma":[0.9969813,0.0006082973,0.0008395803,0.00006540857,0.000008932556,0.00003579339,0.0005577306,0.000009039255,0.0008938735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008290945,"threshold_uncertainty_score":0.002773643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02081744247874157,"score_gpt":0.2731784263610081,"score_spread":0.2523609838822666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}