{"id":"W2941167335","doi":"10.1016/j.jmb.2019.04.027","title":"Nascent β Structure in the Elongated Hydrophobic Region of a Gerstmann–Sträussler–Scheinker PrP Allele","year":2019,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Prion Research Institute; Canadian Institutes of Health Research","keywords":"Valine; Methionine; Allele; Peptide sequence; Pathogenesis; Chemistry; Sequence (biology); Fibril; Prion protein; Biophysics; Amino acid; Protein structure; Biology; Genetics; Stereochemistry; Crystallography; Biochemistry; Gene; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007680727,0.0002220428,0.0001146549,0.0001558236,0.0001153719,0.00009546697,0.00009202531,0.0001659888,0.001466141],"category_scores_gemma":[0.0001507783,0.00006925155,0.0001428009,0.00006076574,0.0001315501,0.00007389619,0.00010226,0.0003204324,0.0002789092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008437625,"about_ca_system_score_gemma":0.00007624943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002586887,"about_ca_topic_score_gemma":0.0004374418,"domain_scores_codex":[0.9999688,0.00000589881,0.000003438466,0.000009840483,0.000006968065,0.000005168694],"domain_scores_gemma":[0.9998428,0.00003255053,0.00005649256,0.00001677819,0.00001233286,0.00003912853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004825771,0.00001107747,0.0004088813,0.000009022303,0.000005719664,0.0003042161,0.00001335647,0.00004027206,0.9985072,0.00009067108,0.00001869993,0.0005427419],"study_design_scores_gemma":[0.00003999973,0.001000884,0.04950772,0.00001254229,0.00005791025,0.005919831,0.00006174947,0.002116433,0.9366243,0.0004641446,0.004176656,0.0000177643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987149,0.00007977375,0.0006262652,0.00001846527,0.000009634779,0.00000710443,0.00007627427,0.00001689809,0.0004506347],"genre_scores_gemma":[0.9980332,0.00005905981,0.0009055873,0.00002552014,0.00000621896,0.000006270689,0.0001946554,0.000006886185,0.0007625788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466141,"threshold_uncertainty_score":0.004904807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004947314854271894,"score_gpt":0.2479768737545283,"score_spread":0.2430295589002564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}