{"id":"W2941193626","doi":"10.1093/neuonc/noz036.170","title":"MEDU-11. MOLECULAR CHARACTERIZATION OF ETMRs REVEALS A ROLE FOR R-LOOP MEDIATED CHROMOSOMAL INSTABILITY","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Somatic cell; Biology; Genome instability; Germline; Chromosome instability; Missense mutation; Gene; Genetics; Allele; Chromosome; Cancer research; DNA; Mutation; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002027661,0.0003016229,0.0002479779,0.0009564917,0.000286359,0.0005007132,0.0002695097,0.0006734257,0.005918779],"category_scores_gemma":[0.0005079124,0.0001588743,0.0002373215,0.0004957804,0.0002529885,0.0002067378,0.0002945322,0.0004261059,0.001848662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003705347,"about_ca_system_score_gemma":0.0001522843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005625313,"about_ca_topic_score_gemma":0.001415515,"domain_scores_codex":[0.9997782,0.00002078484,0.00002272507,0.00007301109,0.00005275579,0.00005244013],"domain_scores_gemma":[0.9996786,0.000075734,0.00007929434,0.0000352178,0.00003799555,0.00009313888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001671861,0.00009679002,0.119862,0.0004286747,0.00007671427,0.005820572,0.0002887038,0.0008265434,0.8290426,0.001128072,0.002583232,0.03817416],"study_design_scores_gemma":[0.00007843989,0.0007668175,0.5002003,0.00008151924,0.0001046688,0.0385641,0.0003144428,0.006889843,0.4011233,0.0008695386,0.05097153,0.00003551456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769554,0.002152895,0.004492338,0.0003325263,0.00006776212,0.00009704819,0.008400547,0.0002926407,0.007208922],"genre_scores_gemma":[0.9718394,0.0006132597,0.007691702,0.0001749202,0.00002219945,0.00008762311,0.01212909,0.00005043903,0.007391266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005918779,"threshold_uncertainty_score":0.01980025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00781702785624331,"score_gpt":0.2546241547081392,"score_spread":0.2468071268518959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}