{"id":"W2941251866","doi":"10.7554/elife.44063","title":"Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells","year":2019,"lang":"en","type":"article","venue":"eLife","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Université Laval","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Alvin J. Siteman Cancer Center; Foundation for Barnes-Jewish Hospital","keywords":"DNA; DNA repair; PALB2; Cell biology; Replication protein A; DNA clamp; HMG-box; Chemistry; Biology; Genetics; RNA; Molecular biology; Computational biology; Gene; Mutation; DNA-binding protein; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008711062,0.0003134467,0.0001255133,0.0001081098,0.0001403725,0.0002485702,0.0002275325,0.0002291964,0.001837583],"category_scores_gemma":[0.00007833526,0.0001122509,0.0001582946,0.00006858932,0.0001795314,0.0001464651,0.0001499131,0.0003240482,0.0004940169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002335022,"about_ca_system_score_gemma":0.0001050128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002644533,"about_ca_topic_score_gemma":0.0004200179,"domain_scores_codex":[0.9999399,0.000007810577,0.000003067259,0.00002407133,0.00001633082,0.000008733844],"domain_scores_gemma":[0.9999586,0.000006441373,0.000007474084,0.000007030565,0.000004811285,0.00001557516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000593516,0.00001453704,0.0001517847,0.00002748532,0.000002861164,0.00009754518,0.000004688111,0.0000416948,0.9983272,0.0001672842,0.00003847161,0.00106706],"study_design_scores_gemma":[0.00002611759,0.0001350317,0.006352088,0.000006555471,0.000009490283,0.001523749,0.00001759117,0.001340526,0.9835306,0.0001881446,0.006864483,0.000005638572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819329,0.004966119,0.008494411,0.0002851039,0.000075746,0.00002129561,0.0005482917,0.0001238419,0.003552247],"genre_scores_gemma":[0.9915662,0.0005219725,0.002523922,0.00006376865,0.00002147597,0.00002124792,0.001209523,0.00001778114,0.004053895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001837583,"threshold_uncertainty_score":0.006147325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01081951730846586,"score_gpt":0.2480350931928445,"score_spread":0.2372155758843786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}