{"id":"W2941282533","doi":"10.1186/s12917-019-1794-z","title":"Prion protein polymorphisms associated with reduced CWD susceptibility limit peripheral PrPCWD deposition in orally infected white-tailed deer","year":2019,"lang":"en","type":"article","venue":"BMC Veterinary Research","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"European Social Fund; Alberta Prion Research Institute; Genome Alberta; Genome Canada","keywords":"Chronic wasting disease; PRNP; Biology; Genotype; Peripheral; Prion protein; Allele; Disease; Virology; Pathology; Genetics; Medicine; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001129461,0.0002780307,0.000180092,0.0005036101,0.0001448437,0.000344924,0.0001460804,0.0003930784,0.001112599],"category_scores_gemma":[0.0003002617,0.0002070464,0.0001617104,0.0002063581,0.000298635,0.0001385616,0.0001886801,0.000306949,0.0003254507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007334151,"about_ca_system_score_gemma":0.00006488001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005364157,"about_ca_topic_score_gemma":0.0007370221,"domain_scores_codex":[0.9998567,0.0000188528,0.00001545755,0.00005809612,0.00002190139,0.00002890791],"domain_scores_gemma":[0.9997182,0.0000364644,0.0001473708,0.00001674688,0.00002470809,0.00005643577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001060037,0.0002040761,0.05149103,0.00004298155,0.00004718125,0.000532219,0.0002520297,0.00007406213,0.944308,0.00007344422,0.00007574885,0.001839223],"study_design_scores_gemma":[0.00007227615,0.001875556,0.9390536,0.00003914916,0.0001510137,0.005662312,0.0006382074,0.0007602543,0.05021746,0.0002088896,0.001288604,0.00003272258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999669,0.00006215092,0.00009848435,0.000003702927,0.000001357048,0.000003070273,0.00004933423,0.000003023186,0.0001099387],"genre_scores_gemma":[0.9989678,0.00008490944,0.0002710179,0.00001785438,0.000003156059,0.000007168174,0.0001736296,0.000006492423,0.0004679342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001112599,"threshold_uncertainty_score":0.003722072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04919185668329181,"score_gpt":0.3261201451458408,"score_spread":0.276928288462549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}