{"id":"W2941309982","doi":"10.1158/1055-9965.epi-18-1235","title":"Analysis of Heritability and Genetic Architecture of Pancreatic Cancer: A PanC4 Study","year":2019,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Center for Chronic Disease Prevention and Health Promotion; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; Ministerstvo Zdravotnictví Ceské Republiky; Wellcome Trust; World Health Organization; National Health and Medical Research Council; Mayo Clinic","keywords":"Heritability; Genome-wide association study; Pancreatic cancer; Linkage disequilibrium; Genetic architecture; Genetic association; Biology; Genetics; Minor allele frequency; Missing heritability problem; Cancer; Allele; Allele frequency; Phenotype; Gene; Genotype; Single-nucleotide polymorphism; Haplotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002683666,0.0005326208,0.0003001556,0.0008103719,0.0004283277,0.0005213462,0.0005313326,0.0003725457,0.001649543],"category_scores_gemma":[0.006327449,0.0003058471,0.001102648,0.00120711,0.0004288463,0.0003619848,0.0009513697,0.0006006359,0.0002022785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003397158,"about_ca_system_score_gemma":0.0003586609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004600619,"about_ca_topic_score_gemma":0.003223947,"domain_scores_codex":[0.9982127,0.0009636337,0.00009904537,0.000448702,0.00017691,0.0000990552],"domain_scores_gemma":[0.9957348,0.001576742,0.001159925,0.001008812,0.0003109326,0.0002088863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002880964,0.0000236478,0.9932296,0.00001860068,0.0005989731,0.0003649106,0.0001885111,0.0005333864,0.0009971334,0.0001349477,0.0002573125,0.003364817],"study_design_scores_gemma":[0.00003347317,0.0001019548,0.9959593,0.00001059945,0.0003691486,0.0005878028,0.0001291676,0.001885807,0.0002057187,0.0002396361,0.0004692426,0.000008118063],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964941,0.0002137557,0.002061326,0.00009278101,0.000005166644,0.00001784607,0.0007128453,0.00001995129,0.0003823102],"genre_scores_gemma":[0.9984158,0.00007917952,0.0008914793,0.00001804303,0.000008272189,0.0000158809,0.0004794203,0.00001286993,0.00007898027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004600619,"threshold_uncertainty_score":0.01419276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05001291721981065,"score_gpt":0.4136387504123865,"score_spread":0.3636258331925759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}