{"id":"W2941309982","doi":"10.1158/1055-9965.epi-18-1235","title":"Analysis of Heritability and Genetic Architecture of Pancreatic Cancer: A PanC4 Study","year":2019,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Center for Chronic Disease Prevention and Health Promotion; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; Ministerstvo Zdravotnictví Ceské Republiky; Wellcome Trust; World Health Organization; National Health and Medical Research Council; Mayo Clinic","keywords":"Heritability; Genome-wide association study; Pancreatic cancer; Linkage disequilibrium; Genetic architecture; Genetic association; Biology; Genetics; Minor allele frequency; Missing heritability problem; Cancer; Allele; Allele frequency; Phenotype; Gene; Genotype; Single-nucleotide polymorphism; Haplotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001751325,0.000177375,0.001851231,0.000354597,0.00003345043,0.000001234639,0.0001072716,0.000194934,0.0005337992],"category_scores_gemma":[0.0005122875,0.0001408791,0.0002790763,0.0006545526,0.0004236013,0.00002875378,0.00007054143,0.0001776048,0.00000177479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000124933,"about_ca_system_score_gemma":0.0002830769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002984611,"about_ca_topic_score_gemma":0.001255526,"domain_scores_codex":[0.9969351,0.001190181,0.0008940681,0.0005019048,0.0001631392,0.0003155796],"domain_scores_gemma":[0.9976513,0.00106436,0.0004795138,0.0005091968,0.0001668593,0.0001287301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00103653,0.0003560207,0.9689016,0.0004511094,0.009096159,0.000002880423,0.0003511461,0.00007468396,0.002654071,0.00001573238,0.00004357841,0.0170165],"study_design_scores_gemma":[0.001697958,0.001188951,0.9859847,0.0001965497,0.007855161,0.000004848213,0.0003441202,0.001850669,0.0000619638,0.0006858895,0.00003125437,0.00009797001],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842965,0.01268491,0.0004922895,0.0006893427,0.00009642971,0.001535608,0.0000307167,0.00001453772,0.0001596581],"genre_scores_gemma":[0.9956586,0.001910263,0.00176957,0.00006995583,0.00002900059,0.0002461528,0.00002512066,0.00001179813,0.0002795343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01708307,"threshold_uncertainty_score":0.5844727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05001291721981065,"score_gpt":0.4136387504123865,"score_spread":0.3636258331925759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}