{"id":"W2941344075","doi":"","title":"Akt phosphorylation and stabilization of XIAP: A major mechanism of Akt-induced cell survival at post-mitochondrial level","year":2004,"lang":"en","type":"article","venue":"","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"XIAP; Protein kinase B; Phosphorylation; Inhibitor of apoptosis; AKT1; Cancer research; AKT2; Cell biology; Apoptosis; Chemistry; Programmed cell death; PI3K/AKT/mTOR pathway; Biology; Signal transduction; Biochemistry; Caspase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009102,0.000263412,0.0001268271,0.0001694532,0.0001745477,0.000277188,0.0001356259,0.0001370024,0.001877474],"category_scores_gemma":[0.00006263579,0.0001110574,0.0002019247,0.0001418902,0.000142492,0.0002090774,0.0001625945,0.0003521889,0.0005659261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003010741,"about_ca_system_score_gemma":0.0002154669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002794568,"about_ca_topic_score_gemma":0.0002784143,"domain_scores_codex":[0.9999301,0.000009439878,0.000006211949,0.00001347625,0.00002095743,0.00001974509],"domain_scores_gemma":[0.9999504,0.000003350325,0.00001832746,0.000008321653,0.000008326852,0.00001124932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002467963,0.00002897238,0.0004886833,0.00006258762,0.000008853064,0.00007374019,0.00001117523,0.000118872,0.9955246,0.0004931156,0.0001007805,0.002841779],"study_design_scores_gemma":[0.00002778815,0.0001453186,0.008725709,0.000006071641,0.00001350312,0.0003185285,0.00001572037,0.0008726186,0.9867874,0.0001781457,0.002905857,0.000003260529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901202,0.003992068,0.00300138,0.0002038597,0.00003759097,0.00001815016,0.0002970546,0.00008902149,0.002240884],"genre_scores_gemma":[0.9948145,0.001337635,0.0008111199,0.00002655601,0.000006111173,0.00001502509,0.0003584738,0.000007669648,0.002622843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001877474,"threshold_uncertainty_score":0.006280839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806081763698877,"score_gpt":0.2499693864739591,"score_spread":0.2319085688369704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}