{"id":"W2941414062","doi":"10.1186/s12941-019-0309-x","title":"Plasma cell-free DNA: a potential biomarker for early prediction of severe dengue","year":2019,"lang":"en","type":"article","venue":"Annals of Clinical Microbiology and Antimicrobials","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Ministry of Education, Culture, Sports, Science and Technology; Japan Agency for Medical Research and Development","keywords":"Dengue fever; Biomarker; Medical microbiology; Cell-free fetal DNA; Parasitology; Virology; Medicine; Computational biology; Internal medicine; Biology; Oncology; Bioinformatics; Immunology; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007611557,0.0004118143,0.000328677,0.001384669,0.0001329794,0.0006700841,0.0002618448,0.0005377341,0.001135561],"category_scores_gemma":[0.002122766,0.0001802711,0.0001859562,0.0007206976,0.000234235,0.0004304658,0.0002451831,0.0003881901,0.0002726496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000313516,"about_ca_system_score_gemma":0.0003807015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009331666,"about_ca_topic_score_gemma":0.0008910269,"domain_scores_codex":[0.9997639,0.00006789532,0.00002628419,0.00005582372,0.00006022884,0.00002586016],"domain_scores_gemma":[0.9987232,0.0004353878,0.0004569268,0.00003682607,0.0002174242,0.0001302632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004995832,0.00006044476,0.9715939,0.0001341478,0.00007537408,0.0001241009,0.00006624631,0.0004755421,0.005656141,0.00007103195,0.0003105991,0.02093302],"study_design_scores_gemma":[0.00005661437,0.001415014,0.9706241,0.0002556932,0.0002085397,0.002729461,0.0003701636,0.009662618,0.008974757,0.0006923261,0.004972751,0.00003797996],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805669,0.01272421,0.003506654,0.0004044308,0.00009026153,0.00006158373,0.001496242,0.00006131234,0.001088361],"genre_scores_gemma":[0.9957219,0.001312202,0.002048118,0.00004837161,0.00004348966,0.00002184992,0.0004652378,0.000002823912,0.00033603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001384669,"threshold_uncertainty_score":0.0040254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03621427735256046,"score_gpt":0.3158912583703072,"score_spread":0.2796769810177467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}