{"id":"W2941439192","doi":"10.1093/neuonc/noz036.112","title":"HGG-18. ALTERNATIVE SPLICING OF NEUROFIBROMIN 1 IS ASSOCIATED WITH ELEVATED MAPK ACTIVITY AND POOR PROGNOSIS IN HIGH-GRADE GLIOMA","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Neurofibromin 1; MAPK/ERK pathway; Glioma; Cancer research; PI3K/AKT/mTOR pathway; Biology; Alternative splicing; RNA splicing; Carcinogenesis; Mutation; Signal transduction; Neurofibromatosis; Medicine; Genetics; Gene; RNA; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001268657,0.0002275236,0.0002042175,0.0004525871,0.0003047975,0.0002916777,0.0001100221,0.0003168251,0.001794217],"category_scores_gemma":[0.0003472458,0.00008893129,0.0002670374,0.0005741811,0.0001957314,0.0001044833,0.0001944012,0.0003696703,0.0003606646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001252897,"about_ca_system_score_gemma":0.0001559357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001123855,"about_ca_topic_score_gemma":0.001592483,"domain_scores_codex":[0.9998599,0.00001428021,0.00001108218,0.00005479051,0.00003014661,0.00002969656],"domain_scores_gemma":[0.9996686,0.00003248439,0.0001750028,0.00001593743,0.00002551025,0.00008238306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001337873,0.00005107358,0.9253297,0.0000752398,0.0001649017,0.001759652,0.0001586429,0.0001578958,0.06019244,0.0000828878,0.0008663845,0.009823309],"study_design_scores_gemma":[0.00001081876,0.0001035515,0.9926035,0.00000688812,0.00005027309,0.002841319,0.00009562227,0.000282448,0.002761709,0.0001196104,0.001118821,0.000005473232],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984285,0.0002539481,0.000192161,0.00003558386,0.000007253893,0.000004964576,0.0008362688,0.00001523918,0.0002261588],"genre_scores_gemma":[0.9980702,0.0001069805,0.0002718018,0.00003176005,0.00001018341,0.000009124416,0.001137288,0.000009760246,0.0003529122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001794217,"threshold_uncertainty_score":0.006002247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0165970455291051,"score_gpt":0.2858020045653725,"score_spread":0.2692049590362673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}