{"id":"W2941474984","doi":"10.3389/fimmu.2019.00879","title":"Expansion of Human NK Cells Using K562 Cells Expressing OX40 Ligand and Short Exposure to IL-21","year":2019,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Ministry of Education, Science and Technology; National Research Foundation of Korea; National Research Foundation","keywords":"Interleukin 12; K562 cells; Interleukin 21; Janus kinase 3; Degranulation; Cell biology; Lymphokine-activated killer cell; Cytotoxic T cell; NK-92; Chemistry; Biology; Cancer research; Molecular biology; Immunology; Cell; T cell; Receptor; In vitro; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001580692,0.0003569702,0.0002096883,0.0001122596,0.0001111151,0.000266393,0.0001300307,0.0001561933,0.001300304],"category_scores_gemma":[0.00008120812,0.0000702412,0.0002111964,0.00009886533,0.000127909,0.0001960719,0.000286534,0.000349336,0.0006510483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001608428,"about_ca_system_score_gemma":0.0001220581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001792427,"about_ca_topic_score_gemma":0.0002640764,"domain_scores_codex":[0.9998274,0.00002736644,0.00002982689,0.00004103541,0.00004491373,0.00002941015],"domain_scores_gemma":[0.9999462,0.00001041928,0.00001050626,0.00001393064,0.000009074242,0.000009904593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009571285,0.00003416707,0.0002447152,0.00002738142,0.000002939323,0.00004325066,0.00001957176,0.0001028444,0.9982355,0.00003636219,0.0000396481,0.001117902],"study_design_scores_gemma":[0.00001364556,0.0001518386,0.001311495,0.000004814031,0.000009288673,0.0002533166,0.000009195529,0.0004710228,0.9950143,0.00001347909,0.002744566,0.000003147145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986889,0.001388147,0.00822265,0.00007588592,0.00004225295,0.0000985965,0.0004201918,0.00007743845,0.002785697],"genre_scores_gemma":[0.9826365,0.0009589188,0.01184336,0.00004844611,0.00001905114,0.0001591063,0.001091292,0.00002854398,0.003214781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001300304,"threshold_uncertainty_score":0.004349947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01005281560432752,"score_gpt":0.2286256161485955,"score_spread":0.218572800544268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}