{"id":"W2941496375","doi":"10.1002/ana.25492","title":"Impact of Diagnosis and Therapy on Cognitive Function in Urea Cycle Disorders","year":2019,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; European Commission; National Institutes of Health; Kettering Fund","keywords":"Neurocognitive; Ornithine transcarbamylase deficiency; Urea cycle; Ornithine transcarbamylase; Pediatrics; Medicine; Hyperammonemia; Citrullinemia; Psychology; Cognition; Internal medicine; Psychiatry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001066538,0.0003025168,0.0004668075,0.0003321955,0.0004259743,0.0004450003,0.0003278846,0.0005030485,0.0007616677],"category_scores_gemma":[0.00563608,0.00007566245,0.0006468071,0.0003667537,0.0002741364,0.0003242822,0.000402326,0.0004329805,0.00008112894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005079834,"about_ca_system_score_gemma":0.0006018256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002700828,"about_ca_topic_score_gemma":0.003405753,"domain_scores_codex":[0.9991902,0.000356668,0.00008747714,0.0001064953,0.0001234228,0.0001358864],"domain_scores_gemma":[0.997847,0.0006841912,0.000889433,0.00007383119,0.000128648,0.0003768673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004797122,0.001831095,0.9610244,0.00007330649,0.0003622836,0.0002933065,0.00008907019,0.0002202426,0.0004171952,0.00002891578,0.0002180054,0.03064517],"study_design_scores_gemma":[0.0001031006,0.00269654,0.9961223,0.00002873105,0.0001261514,0.0002829502,0.00005631311,0.0002068833,0.0001931632,0.00003472333,0.0001444893,0.000004624958],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979601,0.001212686,0.00005403774,0.0001103742,0.00001076047,0.00001192934,0.0001034847,0.00000477348,0.0005318556],"genre_scores_gemma":[0.9995838,0.0001347589,0.00004436421,0.00004156874,0.00001360609,0.000007845472,0.000114124,6.268784e-7,0.00005932874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002700828,"threshold_uncertainty_score":0.005640447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01885004208316593,"score_gpt":0.3045813556076493,"score_spread":0.2857313135244833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}