{"id":"W2941496375","doi":"10.1002/ana.25492","title":"Impact of Diagnosis and Therapy on Cognitive Function in Urea Cycle Disorders","year":2019,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; European Commission; National Institutes of Health; Kettering Fund","keywords":"Neurocognitive; Ornithine transcarbamylase deficiency; Urea cycle; Ornithine transcarbamylase; Pediatrics; Medicine; Hyperammonemia; Citrullinemia; Psychology; Cognition; Internal medicine; Psychiatry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007686809,0.00008770689,0.000156256,0.00006599833,0.000006862766,0.000001587601,0.00005457826,0.0000926424,0.00004554233],"category_scores_gemma":[0.00004249801,0.00007523179,0.0000700772,0.00006051685,0.00007748271,0.000002242664,0.00002417202,0.00004870781,0.000002808721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":9.000649e-8,"about_ca_system_score_gemma":0.00001628959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001110001,"about_ca_topic_score_gemma":0.00003893214,"domain_scores_codex":[0.9994128,0.00007763637,0.000131302,0.0001996015,0.0000491235,0.0001295739],"domain_scores_gemma":[0.9996937,0.00004102581,0.00007256589,0.0001311671,0.00003590652,0.00002567116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002037309,0.0003108789,0.9171738,0.00001294358,0.0000849104,3.804071e-7,0.0000638153,0.0002906803,0.02220904,0.00005125168,0.000319783,0.05744519],"study_design_scores_gemma":[0.001015939,0.004652204,0.9817966,0.000004683434,0.000005416671,7.065468e-7,0.00001084661,0.00001478299,0.01056879,0.000527169,0.001334155,0.00006871122],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963873,0.002370987,0.00000562952,0.0002359485,0.0000598879,0.0001759784,0.00001843293,0.000001486227,0.0007443478],"genre_scores_gemma":[0.9869659,0.01215678,0.000001685716,0.0008068404,0.00001437918,0.00001228218,0.00001979224,0.000008541688,0.00001382818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06462277,"threshold_uncertainty_score":0.3067863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01885004208316593,"score_gpt":0.3045813556076493,"score_spread":0.2857313135244833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}