{"id":"W2941501526","doi":"10.1016/j.cgh.2019.04.047","title":"Sorting Through the Risks and Benefits of Thiopurine Therapy for Inflammatory Bowel Diseases","year":2019,"lang":"en","type":"letter","venue":"Clinical Gastroenterology and Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Shire Canada; Janssen Canada; Merck Canada; Takeda Canada; Merck; Pfizer Canada; AbbVie Canada","keywords":"Medicine; Thiopurine methyltransferase; Inflammatory Bowel Diseases; Inflammatory bowel disease; Azathioprine; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003326016,0.0004240169,0.001256561,0.0008071986,0.001973087,0.002907197,0.0007215487,0.02530328,0.003476904],"category_scores_gemma":[0.02758287,0.0004080194,0.0007533916,0.0006235128,0.002713431,0.002764331,0.000997848,0.02117747,0.003119523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003301484,"about_ca_system_score_gemma":0.002172605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001867073,"about_ca_topic_score_gemma":0.003881194,"domain_scores_codex":[0.9960109,0.002137221,0.0004963497,0.0002179605,0.0007775048,0.0003601645],"domain_scores_gemma":[0.9853224,0.01011387,0.0006230169,0.0003609051,0.002012256,0.001567623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000511439,0.0001157997,0.004764542,0.0001098268,0.00007784689,0.007022462,0.0001764882,0.0001887346,0.0005291221,0.006640122,0.9239542,0.05590953],"study_design_scores_gemma":[0.0009842442,0.0004168442,0.009318419,0.001053519,0.0001782194,0.0205135,0.0011496,0.002493054,0.0009481193,0.09135063,0.8713716,0.0002222953],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001019324,0.002315769,0.0001213739,0.9866846,0.007495098,0.000005641677,0.00002050064,0.00001122069,0.002326577],"genre_scores_gemma":[0.02376587,0.002983807,0.0004517307,0.8510089,0.1177804,0.00002745684,0.00003000678,0.00002123405,0.003930592],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02530328,"threshold_uncertainty_score":0.02395409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04306925468972269,"score_gpt":0.3201325663663716,"score_spread":0.2770633116766489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}