{"id":"W2941514458","doi":"10.1039/c9nr02004g","title":"Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads","year":2019,"lang":"en","type":"article","venue":"Nanoscale","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada); University of British Columbia","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Canadian Institutes of Health Research; British Columbia Innovation Council; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Macromolecule; Fusion; Nanoparticle; Nanotechnology; Materials science; Chemistry; Chemical engineering; Biophysics; Biochemistry; Engineering; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001707013,0.0001495518,0.0001015888,0.00008951419,0.00009487526,0.0001407374,0.0001537696,0.0001733597,0.0003684358],"category_scores_gemma":[0.0002206152,0.0001063545,0.0001372358,0.00007077871,0.0002185627,0.0002402064,0.0002373122,0.0003075821,0.000147331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002892979,"about_ca_system_score_gemma":0.000155872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003104438,"about_ca_topic_score_gemma":0.0003337949,"domain_scores_codex":[0.9999373,0.00001017743,0.000005216968,0.00001479184,0.00002122789,0.0000113264],"domain_scores_gemma":[0.9999253,0.00002141307,0.00002248479,0.000008382343,0.00001325736,0.000009155352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001808292,0.000003470002,0.00003668404,0.00001023765,0.000001552066,0.00002271536,0.00002065107,0.00007042768,0.9991034,0.0002006661,0.00001200221,0.0005000891],"study_design_scores_gemma":[0.000001975809,0.00002585862,0.0001478673,7.870636e-7,0.000001542941,0.00004330896,0.000002989476,0.0005620646,0.9988112,0.00002993231,0.000370996,0.000001335755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886454,0.0003101643,0.009181366,0.00006325501,0.000009894899,0.00002645614,0.00007054688,0.00005908263,0.001633889],"genre_scores_gemma":[0.9949411,0.0001745793,0.003610611,0.00002705122,0.000002048112,0.00001750887,0.00009684199,0.00001426139,0.001115908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003684358,"threshold_uncertainty_score":0.002098978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007978768954476937,"score_gpt":0.2290436627757463,"score_spread":0.2210648938212693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}