{"id":"W2941564931","doi":"10.3390/cancers11040571","title":"Chronic Treatment with Multi-Kinase Inhibitors Causes Differential Toxicities on Skeletal and Cardiac Muscles","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Greenfield Research (Canada)","funders":"V Foundation for Cancer Research; American Cancer Society","keywords":"Skeletal muscle; Wasting; Cachexia; Medicine; Protein kinase B; Sarcopenia; PI3K/AKT/mTOR pathway; Internal medicine; Endocrinology; Muscle atrophy; Cardiac muscle; Muscle weakness; Atrophy; Myocyte; Sorafenib; Heart failure; Pharmacology; Phosphorylation; Cancer; Biology; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001048171,0.0003531937,0.0004001818,0.0001626877,0.0001055249,0.000197719,0.0001283414,0.0001825803,0.001052145],"category_scores_gemma":[0.00006022813,0.0001031503,0.0002395598,0.0001299356,0.0001711564,0.0001644509,0.0001612186,0.0005248569,0.0001636375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001678625,"about_ca_system_score_gemma":0.0001448292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002027471,"about_ca_topic_score_gemma":0.0006808015,"domain_scores_codex":[0.9999001,0.00001137453,0.000008366687,0.00003445026,0.00002219529,0.000023507],"domain_scores_gemma":[0.9999275,0.000007553309,0.00003213757,0.000007966738,0.000005959469,0.00001886467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005491759,0.0001118959,0.001136149,0.00009206351,0.00002084708,0.00009166402,0.00001297019,0.00006355457,0.9935349,0.00005546945,0.00006492152,0.004266392],"study_design_scores_gemma":[0.0001051692,0.00733703,0.09670658,0.00003929707,0.0001250968,0.001433547,0.0001018526,0.0007274859,0.8880802,0.0001278901,0.005201183,0.00001477359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906131,0.006484003,0.001221609,0.0001040319,0.00003007939,0.00002650245,0.000432474,0.00004897916,0.001039172],"genre_scores_gemma":[0.9938982,0.003025217,0.0007990964,0.00008958677,0.00001247636,0.00004804893,0.0004918468,0.00001323877,0.001622282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001052145,"threshold_uncertainty_score":0.003519773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007220149497235041,"score_gpt":0.2300088819409918,"score_spread":0.2227887324437568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}