{"id":"W2941629717","doi":"10.1016/j.bioorg.2019.102952","title":"Design, synthesis and molecular docking of new N-4-piperazinyl ciprofloxacin-triazole hybrids with potential antimicrobial activity","year":2019,"lang":"en","type":"article","venue":"Bioorganic Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; University of British Columbia","keywords":"Antimycobacterial; Chemistry; DNA gyrase; Ciprofloxacin; Docking (animal); Triazole; Topoisomerase; Stereochemistry; Antimicrobial; Topoisomerase IV; Combinatorial chemistry; Active site; In vitro; Biochemistry; Enzyme; Mycobacterium tuberculosis; Organic chemistry; Antibiotics; Escherichia coli","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008668916,0.0002765362,0.0002304997,0.0001432728,0.0001745566,0.0002785773,0.0004588604,0.0003378899,0.001649591],"category_scores_gemma":[0.0001449013,0.00015033,0.0001945254,0.0001669521,0.0001121739,0.000193278,0.0002082575,0.000366779,0.0004932242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005031696,"about_ca_system_score_gemma":0.0002698334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001268627,"about_ca_topic_score_gemma":0.002810391,"domain_scores_codex":[0.9999371,0.000008907725,0.000003575844,0.00001103423,0.00001842554,0.00002097805],"domain_scores_gemma":[0.9999577,0.000005195536,0.00001362223,0.000003291865,0.000006045855,0.00001420347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003202198,0.000114579,0.0003304489,0.0001171188,0.00002321176,0.0002100806,0.00003484804,0.00790691,0.9775425,0.0009236535,0.0003024482,0.01217402],"study_design_scores_gemma":[0.0002069245,0.001562752,0.001848855,0.00002200045,0.00005753284,0.0004152027,0.00007300734,0.0317998,0.9532457,0.0001509329,0.0105644,0.0000528673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788714,0.001159157,0.01520483,0.0001761071,0.00003252349,0.0001304994,0.0002079827,0.0002464675,0.003971],"genre_scores_gemma":[0.983867,0.0004693431,0.01212265,0.00004314595,0.000003274655,0.00006616965,0.0002346967,0.00001738972,0.003176211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001649591,"threshold_uncertainty_score":0.005518436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006982174507192991,"score_gpt":0.204041718154977,"score_spread":0.197059543647784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}