{"id":"W2941726777","doi":"10.1101/618090","title":"HIV chromatin is a preferred target for drugs that bind in the DNA minor groove","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Directorate for Biological Sciences; Purdue University","keywords":"Nucleosome; Chromatin; DNA; Nuclease; Histone; Minor groove; Biology; Micrococcal nuclease; Molecular biology; Histone octamer; Cell biology; Genetics; Chemistry; Biophysics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001305986,0.0001959546,0.0003095525,0.0001519275,0.0001770668,0.0003563443,0.0001707161,0.0002605233,0.002763386],"category_scores_gemma":[0.0001931618,0.0001914914,0.0001989908,0.0000799156,0.0002242919,0.0001356184,0.0001731118,0.0003430631,0.0004701848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001933118,"about_ca_system_score_gemma":0.0001684596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005252593,"about_ca_topic_score_gemma":0.0006402523,"domain_scores_codex":[0.9998502,0.00002602649,0.000008983952,0.00003852751,0.00004290588,0.00003340016],"domain_scores_gemma":[0.9997705,0.00006143338,0.00004956921,0.00002314136,0.00004964869,0.00004569405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006788569,0.0000116997,0.0003337346,0.00002435142,0.000006296541,0.00001642062,0.000005612488,0.00004828249,0.9982722,0.00006860885,0.00002367105,0.001121367],"study_design_scores_gemma":[0.0000140502,0.0005106708,0.004219946,0.000007838345,0.00001363585,0.0002200285,0.0000225009,0.0005325399,0.992402,0.00005655392,0.00199622,0.000004145213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880697,0.003803879,0.004343314,0.0001036215,0.00005459282,0.0000447135,0.0002210097,0.0001443738,0.003214738],"genre_scores_gemma":[0.9974572,0.0003858071,0.0007172109,0.00007222775,0.000008425837,0.00001063459,0.0001295668,0.00001497318,0.001204056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002763386,"threshold_uncertainty_score":0.009244442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02121803090663704,"score_gpt":0.2404777622530244,"score_spread":0.2192597313463874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}