{"id":"W2941729594","doi":"10.29245/2578-3009/2019/1.1167","title":"Commentary: Small Molecule Inhibition of PD-1 Transcription is an Effective Alternative to Antibody Blockade in Cancer Therapy","year":2019,"lang":"en","type":"article","venue":"Journal of Immunological Sciences","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"Cancer Research UK","keywords":"Blockade; Antibody; Small molecule; Cancer research; Cancer therapy; Cancer; Transcription (linguistics); Medicine; Chemistry; Pharmacology; Immunology; Internal medicine; Biochemistry; Receptor; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003676105,0.001778912,0.001530368,0.0007608232,0.001708311,0.00245658,0.004304431,0.027066,0.01167076],"category_scores_gemma":[0.01213545,0.0006842512,0.001776538,0.000819888,0.002575775,0.003467732,0.001051318,0.03571139,0.01192564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002716555,"about_ca_system_score_gemma":0.002522062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002701648,"about_ca_topic_score_gemma":0.004431455,"domain_scores_codex":[0.9972703,0.0005242877,0.0003520872,0.0004592976,0.001169906,0.0002240355],"domain_scores_gemma":[0.9886668,0.005848017,0.0005705793,0.0002871766,0.003393871,0.001233683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009612858,0.00002869528,0.00005193122,0.0002197725,0.00001888699,0.0001887893,0.00002620216,0.00006236371,0.0003807963,0.001180562,0.9867662,0.01097969],"study_design_scores_gemma":[0.00008620178,0.000088883,0.0003979363,0.0002376497,0.00003794689,0.0002900982,0.00005122213,0.0001614259,0.0004071851,0.002659935,0.9955471,0.00003439842],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0003612248,0.0107557,0.0005375831,0.6043787,0.3789476,0.00006035353,0.0003085941,0.0001687586,0.004481633],"genre_scores_gemma":[0.002537233,0.009047116,0.0006567949,0.6116433,0.3611918,0.00007443821,0.0001118026,0.00006276353,0.01467465],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.027066,"threshold_uncertainty_score":0.03904259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03844805750327308,"score_gpt":0.3467796508385664,"score_spread":0.3083315933352933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}