{"id":"W2941739164","doi":"10.1021/jacs.9b02872","title":"Synthesis of an Undecasaccharide Featuring an Oligomannosidic Heptasaccharide and a Bacterial Kdo-lipid A Backbone for Eliciting Neutralizing Antibodies to Mammalian Oligomannose on the HIV-1 Envelope Spike","year":2019,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Michael Smith Health Research BC; University of California, San Francisco; Austrian Science Fund; Canadian Institutes of Health Research; National Institute for Health and Care Research; National Institutes of Health","keywords":"Chemistry; Glycan; Epitope; Mannose; Glycosylation; Glycoconjugate; Tetrasaccharide; Glycoprotein; Antibody; Biochemistry; Stereochemistry; Residue (chemistry); Disaccharide; Polysaccharide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006237231,0.0003658397,0.0008029658,0.00003436709,0.0002103593,0.0001171384,0.000901317,0.0001308894,0.0001066876],"category_scores_gemma":[0.0005127763,0.0002420959,0.0006109338,0.0002948839,0.0003449558,0.0002108205,0.0002251171,0.0004838713,0.000003770726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001656649,"about_ca_system_score_gemma":0.00009348438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008089595,"about_ca_topic_score_gemma":0.000002528062,"domain_scores_codex":[0.9978748,0.00007051583,0.0007304083,0.0004045379,0.0004289704,0.000490755],"domain_scores_gemma":[0.9969748,0.0009139188,0.001050408,0.0006133033,0.0001822908,0.0002652483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005075408,0.0001208274,0.001423025,0.0001737582,0.0001810826,0.000002736342,0.0009130638,0.00003372443,0.994832,0.00002123526,0.0004481719,0.001342804],"study_design_scores_gemma":[0.0003741329,0.00009129791,0.001119521,0.0004191507,0.000158257,0.00007941005,0.003276185,0.0001558683,0.9934613,0.00005679977,0.0005005007,0.0003075412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971116,0.00002440228,0.000009750022,0.002263177,0.0001010263,0.0001620657,0.0001243547,0.00002165268,0.0001819569],"genre_scores_gemma":[0.9965118,0.00005388755,0.00198441,0.0005452135,0.0007686156,0.0000171853,0.00000661498,0.00005537072,0.0000569608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002363121,"threshold_uncertainty_score":0.9872385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01602579487931023,"score_gpt":0.2521485914852789,"score_spread":0.2361227966059686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}