{"id":"W2941755333","doi":"10.1073/pnas.1900867116","title":"Genome-wide CRISPR screen for Zika virus resistance in human neural cells","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Howard Hughes Medical Institute","keywords":"CRISPR; Biology; Zika virus; Arbovirus; Virology; Genome; Neural stem cell; Sindbis virus; Virus; Genetics; Cell biology; Gene; RNA; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002502252,0.000294471,0.0005292338,0.0002895471,0.0001987794,0.0004209292,0.0003744499,0.0004332637,0.001813053],"category_scores_gemma":[0.0002220193,0.0001932867,0.0003676232,0.0001939045,0.0001586851,0.00009226931,0.0003512892,0.000471849,0.0006048771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002485884,"about_ca_system_score_gemma":0.0002463554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001068807,"about_ca_topic_score_gemma":0.002241041,"domain_scores_codex":[0.9997322,0.00003258028,0.00003641845,0.00006559967,0.00009425107,0.00003884073],"domain_scores_gemma":[0.9998978,0.0000319094,0.00001814755,0.00001955588,0.00001827954,0.00001435881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005090794,0.00002726481,0.0003013018,0.00004520068,0.00001727854,0.000142163,0.00001619958,0.0001609395,0.9960348,0.0001056229,0.0002307598,0.002867521],"study_design_scores_gemma":[0.00005068086,0.0004252322,0.006649601,0.00001951295,0.0001268931,0.001395008,0.00006768461,0.004178546,0.9730462,0.0001007687,0.01392025,0.00001956502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9416333,0.002370653,0.03859939,0.0003469895,0.0001498282,0.0006069488,0.006546891,0.00109021,0.008655683],"genre_scores_gemma":[0.9593728,0.001777088,0.02367816,0.0002683656,0.00001178865,0.0002575949,0.006114805,0.0001543498,0.008365049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001813053,"threshold_uncertainty_score":0.006065249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0296670049761006,"score_gpt":0.3169184255762994,"score_spread":0.2872514206001988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}