{"id":"W2941792296","doi":"10.1038/s41598-019-42864-w","title":"The immune mediated role of extracellular HMGB1 in a heterotopic model of bladder cancer radioresistance","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Radioresistance; Bladder cancer; Immune system; Cancer research; Radiation therapy; Cystectomy; Medicine; Tumor microenvironment; Radiosensitivity; HMGB1; Cancer cell; Cancer; Extracellular; Immunology; Biology; Internal medicine; Inflammation; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008198109,0.00006917132,0.0001156867,0.00004939806,0.00004739341,0.00001540184,0.000193268,0.00005130125,0.00003840883],"category_scores_gemma":[0.0001418724,0.00005288771,0.00003978724,0.0002059588,0.0002144033,0.000009537268,0.00006121644,0.0000627982,0.00000178042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001307702,"about_ca_system_score_gemma":0.0002142433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002900881,"about_ca_topic_score_gemma":0.00006420932,"domain_scores_codex":[0.9987047,0.00004885859,0.0003875458,0.0003942955,0.0002838293,0.000180758],"domain_scores_gemma":[0.9985101,0.00001088275,0.000235363,0.0009872515,0.0002216305,0.00003472821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003010409,0.00003491931,0.003110807,0.00001685504,0.000009990485,0.000001498825,0.00008080761,0.008135503,0.9875365,0.00005113099,0.00005102232,0.0009408459],"study_design_scores_gemma":[0.0001209875,0.00002727575,0.0008612759,0.00001277418,0.000002266069,0.000003182333,0.0000651681,0.003502237,0.9806409,0.001251328,0.01344714,0.00006543317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885299,0.01023137,0.000171029,0.00004683659,0.0003765569,0.0003505366,0.000004797368,0.000002836334,0.0002861687],"genre_scores_gemma":[0.9917332,0.0001496102,0.0002629928,0.000002189031,0.00001460158,0.00003564629,0.00003612131,0.000009353835,0.007756265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01339611,"threshold_uncertainty_score":0.2156698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009538704763490006,"score_gpt":0.2688922907244616,"score_spread":0.2593535859609716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}