{"id":"W2941797036","doi":"10.1016/j.eururo.2019.04.006","title":"Clinical Utility of Circulating Tumour Cell Androgen Receptor Splice Variant-7 Status in Metastatic Castration-resistant Prostate Cancer","year":2019,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"DOD Prostate Cancer Research Program; National Cancer Institute; Medical Research Council; Imperial Experimental Cancer Medicine Centre; Stand Up To Cancer; Cancer Research UK; Academy of Medical Sciences; U.S. Department of Veterans Affairs; Patrick C. Walsh Prostate Cancer Research Fund; Institute for Prostate Cancer Research; Prostate Cancer Foundation; Movember Foundation; National Institutes of Health; Prostate Cancer UK; National Institute for Health and Care Research; U.S. Department of Defense","keywords":"Medicine; Prostate cancer; Interquartile range; Circulating tumor cell; Androgen receptor; Biopsy; Internal medicine; Hazard ratio; Oncology; Liquid biopsy; Pathology; Cancer; Confidence interval; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007395017,0.0001953706,0.000357221,0.0005403071,0.0001742184,0.0005223986,0.0002749866,0.0002665163,0.001049311],"category_scores_gemma":[0.003137109,0.00009093098,0.000151216,0.0004481105,0.0002993146,0.000173883,0.0002786368,0.0003218567,0.0001861919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002557137,"about_ca_system_score_gemma":0.0001970279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001425187,"about_ca_topic_score_gemma":0.002450919,"domain_scores_codex":[0.9995635,0.0001352277,0.00004336019,0.00009605614,0.000124845,0.00003695409],"domain_scores_gemma":[0.9980257,0.0007596209,0.0006007134,0.0001057971,0.0002793314,0.0002288904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007210672,0.00002199138,0.9894335,0.00003475467,0.00004766652,0.0001373636,0.00005121367,0.000197138,0.002883559,0.00002342555,0.0001189743,0.006329384],"study_design_scores_gemma":[0.00003162897,0.0005756211,0.993861,0.00001712099,0.00006500132,0.001437014,0.00009370515,0.001305281,0.002090598,0.00006469069,0.0004501997,0.000008116108],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981376,0.001007802,0.0001932618,0.00002898597,0.000008777459,0.00000717839,0.0001930424,0.0000116751,0.0004115423],"genre_scores_gemma":[0.9995901,0.00007281561,0.0001249467,0.00001009868,0.000008788948,0.000002784137,0.0001496087,0.000001598385,0.00003922582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001425187,"threshold_uncertainty_score":0.003910899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04920556836931989,"score_gpt":0.3493108338620497,"score_spread":0.3001052654927298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}