{"id":"W2941922482","doi":"10.1093/neuonc/noz036.204","title":"MEDU-46. SONIC HEDGEHOG SPEEDS UP DNA REPLICATION AND CAUSES CANCER-INITIATING MUTATIONS","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Sonic hedgehog; Biology; DNA damage; Cancer research; Genome instability; DNA repair; DNA replication; PTCH1; Genetics; DNA; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002343563,0.0001821733,0.0002597103,0.00006394603,0.0001526362,0.00002055843,0.0001534272,0.0002021012,0.00004636808],"category_scores_gemma":[0.0004992945,0.0001862353,0.00005893525,0.0001199374,0.0001395183,0.000007064426,0.0001697158,0.000163426,0.00004884155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005814873,"about_ca_system_score_gemma":0.000253255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005099469,"about_ca_topic_score_gemma":0.0002013794,"domain_scores_codex":[0.9985064,0.0001567602,0.0002901628,0.0006298106,0.0001057509,0.0003111181],"domain_scores_gemma":[0.9989526,0.00016185,0.0001809195,0.0004735362,0.0001424181,0.00008863735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003168776,0.0000317512,0.009206668,0.00002842589,0.00005514647,0.000006106111,0.0003805396,0.00005754621,0.9766106,0.00009926629,0.0009428497,0.01254939],"study_design_scores_gemma":[0.001053541,0.0009471628,0.007011239,0.00002133678,0.00008210899,0.00009193947,0.0006201572,0.0001929456,0.7604101,0.0001119422,0.2291319,0.0003256272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932531,0.00116549,0.00008786391,0.001249655,0.0007229987,0.0003576348,0.00003160306,0.00004213272,0.003089536],"genre_scores_gemma":[0.9968339,0.0006060849,0.0002350885,0.001471895,0.0003484948,0.0001016372,0.00007294607,0.00003629951,0.0002936692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2281891,"threshold_uncertainty_score":0.7594454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03350962826161385,"score_gpt":0.329669469553169,"score_spread":0.2961598412915551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}