{"id":"W2941929477","doi":"10.1021/acs.bioconjchem.9b00225","title":"Functionally Versatile and Highly Stable Chelator for <sup>111</sup>In and <sup>177</sup>Lu: Proof-of-Principle Prostate-Specific Membrane Antigen Targeting","year":2019,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; TRIUMF","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Biodistribution; Bioconjugation; DOTA; Chelation; Conjugated system; Combinatorial chemistry; Ligand (biochemistry); Bifunctional; Linker; Stereochemistry; In vitro; Biochemistry; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002064575,0.000469554,0.0003162312,0.000100986,0.0002018001,0.0004040088,0.0003991094,0.0004463496,0.00159455],"category_scores_gemma":[0.0002200253,0.0001644822,0.0001439982,0.0001179001,0.0003061862,0.0003530986,0.0003926366,0.0005038634,0.0009269582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003422748,"about_ca_system_score_gemma":0.000341415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004223897,"about_ca_topic_score_gemma":0.0006033732,"domain_scores_codex":[0.9998922,0.00002566985,0.000004982216,0.00002986668,0.00002233922,0.00002497645],"domain_scores_gemma":[0.9999309,0.000009302436,0.00001766225,0.000008421332,0.0000176633,0.00001611742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006135167,0.000009039556,0.00005547151,0.00008645449,0.000004121202,0.00005730003,0.0000312767,0.00004793381,0.9948376,0.0008093253,0.0005455886,0.003454499],"study_design_scores_gemma":[0.000008005428,0.0001073925,0.0002720698,0.000004636625,0.00001093088,0.0003788707,0.00001865361,0.0002343148,0.9808294,0.0001160333,0.01801083,0.000009064351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7937005,0.01840655,0.140412,0.003434241,0.0009477618,0.0002870783,0.001054079,0.002126745,0.03963106],"genre_scores_gemma":[0.939236,0.003208136,0.03553534,0.0007532619,0.00008557191,0.0001094828,0.0006954084,0.000226917,0.02014988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00159455,"threshold_uncertainty_score":0.005334258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01628693543535186,"score_gpt":0.2639160517781075,"score_spread":0.2476291163427556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}