{"id":"W2941929477","doi":"10.1021/acs.bioconjchem.9b00225","title":"Functionally Versatile and Highly Stable Chelator for <sup>111</sup>In and <sup>177</sup>Lu: Proof-of-Principle Prostate-Specific Membrane Antigen Targeting","year":2019,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; TRIUMF","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Biodistribution; Bioconjugation; DOTA; Chelation; Conjugated system; Combinatorial chemistry; Ligand (biochemistry); Bifunctional; Linker; Stereochemistry; In vitro; Biochemistry; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003190233,0.0003055536,0.0004881117,0.00003681999,0.0001059673,0.00004008201,0.0001274444,0.0002417564,0.0003953596],"category_scores_gemma":[0.0000854109,0.0002973352,0.00008889945,0.0002042011,0.0002015341,0.0001331867,0.00008335797,0.000303581,0.00001142317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008440481,"about_ca_system_score_gemma":0.0001534773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000678962,"about_ca_topic_score_gemma":1.059223e-7,"domain_scores_codex":[0.9980588,0.00001267446,0.0005411403,0.0006870585,0.0002461298,0.0004541793],"domain_scores_gemma":[0.9988846,0.0001567536,0.0001511771,0.000368191,0.000145764,0.0002935633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000695688,0.0002255218,0.009044155,0.002898367,0.00008593696,0.000007105931,0.000301246,0.0003718548,0.9852287,0.0001029408,0.0005848944,0.0004535838],"study_design_scores_gemma":[0.00352432,0.00007966162,0.0005735586,0.0001865609,0.00004832864,0.0000309447,0.0006571606,0.008074301,0.9175022,0.00008175127,0.06893294,0.0003083286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937009,0.001717361,0.00003280654,0.0006023042,0.00001886734,0.001319417,0.0002200923,0.00005894157,0.00232927],"genre_scores_gemma":[0.9946703,0.0002789164,0.001286222,0.00008314987,0.0002257483,0.0002210146,0.0003956019,0.00004813161,0.002790947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06834804,"threshold_uncertainty_score":0.9999479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01628693543535186,"score_gpt":0.2639160517781075,"score_spread":0.2476291163427556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}