{"id":"W2942029156","doi":"10.1101/618397","title":"<i>Plasmodium</i> secretion induces hepatocyte lysosome exocytosis and promotes parasite entry","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Lysosome; Exocytosis; Cell biology; Secretion; Biology; Plasmodium (life cycle); LAMP1; Lipid bilayer fusion; Rab; Endosome; Virology; Parasite hosting; GTPase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009399833,0.0001590693,0.000178878,0.0001002954,0.0001080397,0.0003107927,0.00007040618,0.0001319369,0.002027271],"category_scores_gemma":[0.00008326069,0.00009797395,0.0001463285,0.00009702487,0.0001210856,0.0001116414,0.0001733954,0.0003284336,0.0008490069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002512474,"about_ca_system_score_gemma":0.0001143016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003937049,"about_ca_topic_score_gemma":0.0004823798,"domain_scores_codex":[0.9999191,0.00001717997,0.000006352656,0.000012774,0.00001843572,0.0000261303],"domain_scores_gemma":[0.9999455,0.00001073744,0.00001162184,0.0000068163,0.000005659119,0.00001973519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001876521,0.00001983067,0.0002059743,0.000036976,0.000002982894,0.00007154699,0.000008981458,0.00002562415,0.9983797,0.0001047276,0.0002072235,0.0007487768],"study_design_scores_gemma":[0.00004094065,0.0002054045,0.01176745,0.000008528968,0.000007494784,0.0002907778,0.00003763545,0.0009908224,0.9832549,0.00007709166,0.003315312,0.000003685621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901935,0.0007892541,0.002438817,0.0002957209,0.00005915614,0.00002935809,0.0007505447,0.0001828925,0.005260684],"genre_scores_gemma":[0.9942172,0.0003661354,0.001090062,0.00008855053,0.00001903851,0.00001763622,0.000764071,0.00004487993,0.00339239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002027271,"threshold_uncertainty_score":0.006781876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01243846403896283,"score_gpt":0.2269335545980355,"score_spread":0.2144950905590727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}