{"id":"W2942034010","doi":"10.1097/mph.0000000000001487","title":"A Rare Case of Activated Phosphoinositide 3-Kinase Delta Syndrome (APDS) Presenting With Hemophagocytosis Complicated With Hodgkin Lymphoma","year":2019,"lang":"en","type":"article","venue":"Journal of Pediatric Hematology/Oncology","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"","keywords":"Hemophagocytic lymphohistiocytosis; Hemophagocytosis; Medicine; Lymphoma; Hematopoietic stem cell transplantation; Ifosfamide; Etoposide; Immunology; Chemotherapy; Pancytopenia; Internal medicine; Transplantation; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007441457,0.0003597273,0.002030979,0.0008206057,0.0001126142,0.00001619292,0.000338131,0.0004319326,0.0003543376],"category_scores_gemma":[0.0002426938,0.0002515687,0.0002309947,0.001152672,0.0002781201,0.0002942524,0.0001416226,0.0007510916,0.00004169806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002999851,"about_ca_system_score_gemma":0.002404181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001263775,"about_ca_topic_score_gemma":0.00001795078,"domain_scores_codex":[0.9966032,0.0003410116,0.001433469,0.0003824081,0.0005541732,0.0006857716],"domain_scores_gemma":[0.9955223,0.0006860595,0.001840109,0.0005105441,0.001092411,0.0003485522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"case_report","study_design_scores_codex":[0.01068095,0.002737269,0.7758482,0.001746856,0.001591501,0.1846606,0.001465565,0.00009671687,0.01490827,0.0001560697,0.003000094,0.003107927],"study_design_scores_gemma":[0.03320914,0.01837359,0.06388616,0.0003644139,0.001743785,0.8189802,0.004953394,0.0004601496,0.05518135,0.00006273945,0.002112889,0.0006721641],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953932,0.001782371,0.0001281767,0.0008879876,0.0001056016,0.000795787,0.00001150541,0.00003823474,0.0008571455],"genre_scores_gemma":[0.9968573,0.0002190999,0.002471371,0.0001463152,0.00008498051,0.00002220723,0.00001431661,0.00006243199,0.000121975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.711962,"threshold_uncertainty_score":0.9999937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01754356486060303,"score_gpt":0.2999914018442378,"score_spread":0.2824478369836347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}