{"id":"W2942062551","doi":"10.1358/dot.2019.55.4.2958476","title":"Encorafenib and binimetinib for the treatment of BRAFV600E/K-mutated melanoma","year":2019,"lang":"en","type":"review","venue":"Drugs of today","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Melanoma; MAPK/ERK pathway; Metastatic melanoma; V600E; Cancer research; Oncology; Kinase; Pharmacology; Mutation; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002481639,0.000605996,0.0007171097,0.001883924,0.0001956706,0.0005221352,0.0005480084,0.000652875,0.004716574],"category_scores_gemma":[0.000325389,0.00016606,0.0004178761,0.001207018,0.0001947569,0.0007188828,0.0003955143,0.001456033,0.002341144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003901703,"about_ca_system_score_gemma":0.0005359141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007050188,"about_ca_topic_score_gemma":0.002323602,"domain_scores_codex":[0.9999064,0.0000123026,0.00001224221,0.00001674428,0.00004126289,0.00001097943],"domain_scores_gemma":[0.9999177,0.0000286588,0.00001514114,0.000002434205,0.00002413265,0.00001199193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008522425,0.00007563192,0.0001156863,0.00818128,0.00007345725,0.0001915146,0.00003549716,0.0002773221,0.002285357,0.001960012,0.03376233,0.9529568],"study_design_scores_gemma":[0.00002489481,0.00009980304,0.0005299507,0.001278883,0.00006886985,0.001328944,0.00001811938,0.00006627305,0.0005066556,0.0006992474,0.9953682,0.00001016367],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002849543,0.9966056,0.000142998,0.0002573525,0.0002481832,0.000009359041,0.0000448315,0.00001316623,0.00239352],"genre_scores_gemma":[0.001192986,0.996086,0.0002001515,0.0002996029,0.0001319904,0.0000110616,0.00008576901,0.000002247735,0.001990222],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004716574,"threshold_uncertainty_score":0.01577854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04074034639323368,"score_gpt":0.3182639523817377,"score_spread":0.277523605988504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}