{"id":"W2942114051","doi":"10.1097/01.ju.0000555586.05782.19","title":"MP22-02 GNRH ANTAGONISTS HAVE DIRECT INHIBITORY EFFECTS ON CASTRATION-RESISTANT PROSTATE CANCER VIA INTRACRINE ANDROGEN AND AR-V7 EXPRESSION","year":2019,"lang":"en","type":"article","venue":"The Journal of Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Intracrine; Prostate cancer; Medicine; Testosterone (patch); Androgen deprivation therapy; Androgen receptor; Androgen; Cancer; Management of prostate cancer; Agonist; Internal medicine; Cancer research; Endocrinology; Receptor; Hormone; Paracrine signalling","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001375251,0.0003006708,0.0002335125,0.000334809,0.0002057832,0.0008372372,0.0002447692,0.0004400446,0.05119872],"category_scores_gemma":[0.0001619663,0.0002419425,0.0003516218,0.0002356203,0.0001743339,0.0002506301,0.0002406098,0.0008143965,0.009323996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002232445,"about_ca_system_score_gemma":0.0004385764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006301188,"about_ca_topic_score_gemma":0.00140614,"domain_scores_codex":[0.999872,0.00001381047,0.000008457221,0.00001609517,0.00006415782,0.00002549708],"domain_scores_gemma":[0.9998908,0.0000186399,0.00001776411,0.000011268,0.00002038731,0.00004115229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001954811,0.000718072,0.001961052,0.0007627438,0.00007824049,0.0005230673,0.00008822355,0.0001818547,0.7915326,0.001370568,0.04629897,0.1545299],"study_design_scores_gemma":[0.0008103576,0.006693202,0.03518118,0.0001912645,0.0001546523,0.003897336,0.0002034823,0.000816924,0.599756,0.0003705501,0.3518718,0.00005326734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.633414,0.07409248,0.005669866,0.006418394,0.003420745,0.0005678424,0.00635833,0.00292316,0.2671352],"genre_scores_gemma":[0.6506237,0.02609374,0.004700618,0.002692483,0.00083524,0.0002939093,0.004980563,0.0004696149,0.3093101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05119872,"threshold_uncertainty_score":0.1712768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00968682037714934,"score_gpt":0.290682486019729,"score_spread":0.2809956656425796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}