{"id":"W2942127610","doi":"10.1021/jacs.8b11912","title":"Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation","year":2019,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; Novartis Institutes for BioMedical Research; National Institutes of Health; Canadian Institute for Advanced Research; University of California Berkeley; Howard Hughes Medical Institute","keywords":"Bioconjugation; Chemistry; Histidine; Combinatorial chemistry; Click chemistry; Cysteine; Covalent bond; Reagent; Azide; Lysine; Bioorthogonal chemistry; Surface modification; Biochemistry; Amino acid; Organic chemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001582469,0.0001516006,0.0003169273,0.00000601761,0.00009486413,0.0000215149,0.0004981612,0.00007573969,0.0001004103],"category_scores_gemma":[0.0001507695,0.0001095148,0.0006228108,0.000274821,0.0002004354,0.00006289685,0.00007983732,0.0003275371,0.000007144611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002695452,"about_ca_system_score_gemma":0.00009385959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001061076,"about_ca_topic_score_gemma":1.129252e-7,"domain_scores_codex":[0.9989324,0.000005805625,0.000398325,0.0001975937,0.0002516335,0.0002142687],"domain_scores_gemma":[0.9981963,0.0001738618,0.0009988053,0.000322581,0.0002181064,0.000090359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001113667,0.00009589142,0.001428439,0.00004606374,0.0001048416,1.143995e-7,0.00009905403,0.000004933168,0.9884838,0.0000198238,0.008526476,0.001079124],"study_design_scores_gemma":[0.0006743404,0.00002495518,0.000191249,0.00004211561,0.00007563287,0.00001707749,0.0002127661,0.0001792285,0.9807808,0.0003279873,0.01734,0.0001338753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970953,0.00004970391,0.00009980975,0.001806009,0.00007734778,0.000106465,0.00004086076,0.0000197071,0.0007047822],"genre_scores_gemma":[0.9966298,0.00005434098,0.001654068,0.0004797663,0.0003969825,0.00001695047,0.00001442617,0.0000218617,0.0007317985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008813528,"threshold_uncertainty_score":0.4465884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00967685738337791,"score_gpt":0.2524968559738956,"score_spread":0.2428199985905177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}