{"id":"W2942128858","doi":"10.1158/1078-0432.ccr-19-0404","title":"Novel RB1-Loss Transcriptomic Signature Is Associated with Poor Clinical Outcomes across Cancer Types","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; Prostate Cancer Foundation","keywords":"Cancer; Prostate cancer; Oncology; DNA methylation; Gene signature; Transcriptome; Internal medicine; Breast cancer; Medicine; Biology; Cancer research; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005905016,0.0002624887,0.0004865055,0.0007780704,0.0002303944,0.0005746421,0.0002902408,0.0002924022,0.001929869],"category_scores_gemma":[0.001315625,0.0001185756,0.0004230483,0.0007833955,0.000230946,0.0002568484,0.000452249,0.0003737733,0.0003860174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000360412,"about_ca_system_score_gemma":0.0003096785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001820544,"about_ca_topic_score_gemma":0.003236297,"domain_scores_codex":[0.9996465,0.00005353335,0.00003313725,0.0001517819,0.00006163143,0.00005336809],"domain_scores_gemma":[0.9992185,0.0002339781,0.0002993577,0.00007599129,0.0000993373,0.00007282762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001596878,0.00005757082,0.9281954,0.0001556382,0.0003623867,0.0001575923,0.00006983477,0.001869171,0.04641925,0.0001128296,0.001169384,0.01983414],"study_design_scores_gemma":[0.00002736526,0.0001984722,0.9824376,0.0000212208,0.000265355,0.0007366861,0.0001156396,0.007142509,0.007352466,0.0003119007,0.001377418,0.00001351442],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910829,0.001103972,0.001803573,0.0001408568,0.000009615026,0.00002349018,0.005067764,0.00008596449,0.0006817825],"genre_scores_gemma":[0.9938022,0.0001621085,0.0007091388,0.0000631287,0.000008606969,0.00002667287,0.004928679,0.00001535884,0.0002841189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001929869,"threshold_uncertainty_score":0.006456077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2342677880658154,"score_gpt":0.5628657953480856,"score_spread":0.3285980072822701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}