{"id":"W2942131522","doi":"","title":"Transcriptomic Impact of IMA-08401, a Novel AHR Agonist Resembling Laquinimod, on Rat Liver","year":2019,"lang":"en","type":"article","venue":"eScholarship (California Digital Library)","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Agonist; Aryl hydrocarbon receptor; Pharmacology; In vivo; Metabolite; Transcriptome; Immune system; Receptor; Toxicity; Ex vivo; Medicine; In vitro; Chemistry; Transcription factor; Internal medicine; Biology; Immunology; Gene expression; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007557123,0.0002866608,0.0003180884,0.0002735957,0.0001546954,0.000227872,0.0000981155,0.0002664448,0.001342416],"category_scores_gemma":[0.00007451599,0.0001036051,0.0003785558,0.0002417601,0.0002067903,0.0001290837,0.0001628326,0.000425693,0.0002801485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001876648,"about_ca_system_score_gemma":0.0001779184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009185261,"about_ca_topic_score_gemma":0.001666198,"domain_scores_codex":[0.9999008,0.000007814384,0.000004326111,0.00003370193,0.00002522875,0.00002806638],"domain_scores_gemma":[0.9999299,0.000009215058,0.00001750992,0.000005159146,0.00001623593,0.0000219482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003503881,0.0000171317,0.0006836728,0.00005438238,0.000009444429,0.00004104183,0.00001648657,0.00006133274,0.9975436,0.00001558939,0.00005369757,0.001153211],"study_design_scores_gemma":[0.00003106262,0.002273602,0.09693202,0.00002893644,0.0001371073,0.0003360893,0.0003749869,0.00106386,0.8932793,0.0001014921,0.005411627,0.00002993083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899686,0.001921867,0.001360723,0.0001203874,0.0000554781,0.00002976969,0.005289705,0.00006778428,0.001185683],"genre_scores_gemma":[0.9849652,0.001771319,0.001531533,0.0002643712,0.00002348403,0.00009582748,0.005311681,0.00003440586,0.006002198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001342416,"threshold_uncertainty_score":0.004490852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01484571830695874,"score_gpt":0.22946738962301,"score_spread":0.2146216713160512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}