{"id":"W2942213721","doi":"10.1371/journal.pone.0215689","title":"Dicer regulates activation of the NLRP3 inflammasome","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"York University; Alpha Foundation for the Improvement of Mine Safety and Health","keywords":"Inflammasome; Dicer; Inflammation; Cell biology; Caspase 1; Secretion; Acquired immune system; microRNA; Biology; Cytokine; Innate immune system; Pyroptosis; Immunology; Immune system; RNA interference; RNA; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004449378,0.0003567191,0.0004432578,0.0003964257,0.0004095085,0.0005982881,0.0002670825,0.0004968041,0.001369417],"category_scores_gemma":[0.0003769726,0.0001726853,0.0003592407,0.0002289808,0.0005265975,0.0004296848,0.000542055,0.0006950682,0.0006413974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004286755,"about_ca_system_score_gemma":0.000267112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002153178,"about_ca_topic_score_gemma":0.0002085408,"domain_scores_codex":[0.9995502,0.000108496,0.00005893359,0.0001152713,0.00009416492,0.00007295171],"domain_scores_gemma":[0.9996909,0.00004451026,0.0001284657,0.00002758665,0.00005403434,0.00005457793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001806593,0.00001139188,0.0006298074,0.0001633753,0.00001243167,0.0007542209,0.00006315345,0.000172005,0.9923654,0.001445696,0.0004215505,0.003780348],"study_design_scores_gemma":[0.00004245422,0.0002082315,0.01160338,0.00003554114,0.00003468894,0.003203012,0.00009629175,0.00123573,0.9586992,0.001374214,0.0234404,0.00002694224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.860916,0.06086767,0.05345921,0.002486636,0.0007919013,0.0001868907,0.002720769,0.0009707711,0.01760016],"genre_scores_gemma":[0.980462,0.006125955,0.009265243,0.0003477756,0.00008351632,0.00003803714,0.0005211552,0.00005671166,0.003099671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001369417,"threshold_uncertainty_score":0.004581153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009516019208213452,"score_gpt":0.1844723537375402,"score_spread":0.1749563345293268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}