{"id":"W2942237294","doi":"10.1016/j.diagmicrobio.2019.03.003","title":"Reproducibility of broth microdilution MICs for the novel siderophore cephalosporin, cefiderocol, determined using iron-depleted cation-adjusted Mueller-Hinton broth","year":2019,"lang":"en","type":"article","venue":"Diagnostic Microbiology and Infectious Disease","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Shionogi; Diagnostic Services Manitoba; University of Manitoba","keywords":"Serial dilution; Broth microdilution; Reproducibility; Cephalosporin; Microbiology; Bacilli; Dilution; Antimicrobial; Chromatography; Siderophore; Minimum inhibitory concentration; Biology; Chemistry; Bacteria; Medicine; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01096462,0.001092821,0.0008540018,0.001347389,0.0006045924,0.001390802,0.0008810771,0.0008050447,0.0008203029],"category_scores_gemma":[0.01994921,0.0005889729,0.0008364373,0.0009493211,0.0009974744,0.0004527775,0.001018948,0.0008027409,0.0007668929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004614473,"about_ca_system_score_gemma":0.0004434152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001415911,"about_ca_topic_score_gemma":0.002097641,"domain_scores_codex":[0.9774767,0.006413694,0.003203172,0.004003228,0.008504228,0.0003990398],"domain_scores_gemma":[0.9810209,0.006661961,0.002239634,0.004837052,0.004934247,0.0003061805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001579804,0.000388626,0.04190985,0.0002684313,0.0002889565,0.0001187072,0.001021143,0.0006233691,0.9364437,0.000199869,0.0005258393,0.01663167],"study_design_scores_gemma":[0.00007036601,0.003452638,0.1172522,0.00007217669,0.0002638508,0.0006390298,0.0003017524,0.002973284,0.8707219,0.0002275209,0.003936445,0.00008887474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9456875,0.001833277,0.04261825,0.0003186614,0.0004332598,0.0006464795,0.002577815,0.000510189,0.005374617],"genre_scores_gemma":[0.9444597,0.0006056187,0.0473444,0.0002635508,0.00009679693,0.0006789892,0.00346009,0.0001963746,0.002894462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01096462,"threshold_uncertainty_score":0.05798715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01181448383242518,"score_gpt":0.2433462368247337,"score_spread":0.2315317529923085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}