{"id":"W2942259759","doi":"10.1093/neuonc/noz036.169","title":"MEDU-10. THERAPEUTIC TARGETING OF STEM CELL SELF-RENEWAL IN CHILDHOOD MEDULLOBLASTOMA: STRATEGIES FOR BLOCKING RECURRENCE","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medulloblastoma; BMI1; Wnt signaling pathway; Cancer research; Neural stem cell; Stem cell; Carcinogenesis; Biology; Medicine; Signal transduction; Internal medicine; Cancer; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001073522,0.0002906759,0.0002579998,0.0003514587,0.0001360261,0.0002660291,0.0003069754,0.0003368308,0.002916527],"category_scores_gemma":[0.00005516235,0.0001017882,0.0002342904,0.0002029391,0.0001853593,0.0001905145,0.0002070029,0.0006789594,0.0007857981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006849591,"about_ca_system_score_gemma":0.0004244429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001304682,"about_ca_topic_score_gemma":0.005830069,"domain_scores_codex":[0.9999431,0.00000623268,0.000004057269,0.0000107566,0.00001814368,0.00001766762],"domain_scores_gemma":[0.9999678,0.000003455563,0.000009332726,0.000002797226,0.000004308227,0.00001240086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001185646,0.0006623765,0.001243274,0.0006519478,0.00005535204,0.0003048381,0.0001054211,0.0009958947,0.9016026,0.002463339,0.002683025,0.08804633],"study_design_scores_gemma":[0.0003052995,0.003600773,0.00716076,0.00005233685,0.000093521,0.001184779,0.00006856991,0.002745404,0.9176807,0.0003228735,0.06676588,0.00001910706],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9305593,0.033781,0.008204719,0.001411783,0.0003090634,0.0002913148,0.002327701,0.0008719019,0.02224328],"genre_scores_gemma":[0.9639788,0.01285667,0.00533215,0.0003046782,0.00003545095,0.0001473496,0.001762853,0.0000494897,0.01553265],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002916527,"threshold_uncertainty_score":0.009756744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01123373838509256,"score_gpt":0.2671099982123849,"score_spread":0.2558762598272923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}