{"id":"W2942554478","doi":"10.1158/1078-0432.ccr-18-2867","title":"Efficacy and Safety Analysis of Nelipepimut-S Vaccine to Prevent Breast Cancer Recurrence: A Randomized, Multicenter, Phase III Clinical Trial","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":213,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation","funders":"","keywords":"Medicine; Interim analysis; Placebo; Breast cancer; Internal medicine; Asymptomatic; Adverse effect; Surgery; Erythema; Biopsy; Cancer; Randomized controlled trial; Gastroenterology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.01578579,0.0002887482,0.002621606,0.0005549956,0.0002011634,0.00003242241,0.0006682016,0.000517496,0.006594191],"category_scores_gemma":[0.00243523,0.0002146192,0.0009217366,0.001170037,0.0009108783,0.0001024855,0.0004198406,0.001497227,0.0001611437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009327245,"about_ca_system_score_gemma":0.0005888864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001867787,"about_ca_topic_score_gemma":0.00017055,"domain_scores_codex":[0.9878952,0.007406018,0.002757961,0.0009400767,0.0002412846,0.0007594661],"domain_scores_gemma":[0.9862498,0.01165968,0.0004700815,0.0008987648,0.0005748128,0.0001468564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8078462,0.002909865,0.002829075,0.0000259672,0.005354302,0.000002104864,0.0002341671,0.00001481772,0.003216264,0.00003608398,0.001646135,0.175885],"study_design_scores_gemma":[0.9314612,0.003906793,0.02768527,0.0003031615,0.001197869,0.000004180125,0.0001177587,0.0001249876,0.001075269,0.00001178865,0.03380243,0.0003092983],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739702,0.01748991,0.00004627147,0.001811195,0.00228178,0.003922282,0.0003787719,0.00002543618,0.00007415446],"genre_scores_gemma":[0.9547785,0.04064169,0.00002347192,0.0003082264,0.0002205432,0.0004020291,0.00007462766,0.00002803765,0.003522881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1755757,"threshold_uncertainty_score":0.9943139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1100018083514575,"score_gpt":0.5228560650361491,"score_spread":0.4128542566846917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}