{"id":"W2942700100","doi":"10.1021/jacs.9b02554","title":"Robustness, Entrainment, and Hybridization in Dissipative Molecular Networks, and the Origin of Life","year":2019,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Simons Foundation","keywords":"Dissipative system; Chemistry; Entrainment (biomusicology); Robustness (evolution); Abiogenesis; Statistical physics; Chemical physics; Thermodynamics; Astrobiology; Physics; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001954833,0.00006372818,0.0002192545,0.000005359228,0.00002374364,0.00001218448,0.00009967739,0.00001087374,0.00001536035],"category_scores_gemma":[0.00001136279,0.00003428775,0.0001279596,0.0001287432,0.0003114719,0.00004936715,0.00005146263,0.0001672268,6.390504e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002091747,"about_ca_system_score_gemma":0.00003591648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004483447,"about_ca_topic_score_gemma":9.701589e-8,"domain_scores_codex":[0.9994641,0.00004866509,0.0002117283,0.00006240594,0.0001225808,0.00009054186],"domain_scores_gemma":[0.9993352,0.00008042327,0.0004358048,0.00007295491,0.00003319732,0.00004246692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002713491,0.0001870069,0.9364603,0.00002644488,0.0004041212,3.205385e-7,0.0008944399,0.0164963,0.03198637,0.007338102,0.003070116,0.002865162],"study_design_scores_gemma":[0.03085719,0.0005389106,0.3035769,0.0007774375,0.000850041,0.00003019948,0.02162393,0.5514033,0.06817351,0.01041841,0.01024428,0.001505938],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935201,0.0001407873,0.004936562,0.001215189,0.00003878992,0.00006540387,0.000003750138,8.487297e-7,0.00007860627],"genre_scores_gemma":[0.9992932,0.00006356664,0.0003420962,0.0001898699,0.0000977443,8.780816e-7,6.348006e-7,0.000004452207,0.000007578114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6328834,"threshold_uncertainty_score":0.1398214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004253615672052931,"score_gpt":0.2225196871377896,"score_spread":0.2182660714657366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}