{"id":"W2942741111","doi":"10.4049/jimmunol.1801464","title":"Critical Role for TCR Signal Strength and MHC Specificity in ThPOK-Induced CD4 Helper Lineage Choice","year":2019,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Cytotoxic T cell; CD8; Biology; MHC class I; Major histocompatibility complex; T-cell receptor; Double negative; Cell biology; Lineage (genetic); MHC class II; Immunology; T cell; Immune system; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365217,0.0003680082,0.0002020541,0.0002288215,0.0001749214,0.0004408628,0.0002513121,0.0002939092,0.001949995],"category_scores_gemma":[0.0001861888,0.0001881363,0.0001846576,0.0001021371,0.0003227748,0.0002927646,0.0002999039,0.0007416611,0.0004659182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000271775,"about_ca_system_score_gemma":0.0001340633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002007255,"about_ca_topic_score_gemma":0.0002623076,"domain_scores_codex":[0.9997569,0.00003759305,0.00003151171,0.00004097054,0.00006653657,0.00006658507],"domain_scores_gemma":[0.9995553,0.00008812339,0.0001422559,0.00005639644,0.00004985553,0.0001080328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003199255,0.000005273092,0.0001371671,0.000009531495,6.102207e-7,0.00001835942,0.000003398226,0.00001099881,0.9996295,0.00002188188,0.000002685471,0.0001286321],"study_design_scores_gemma":[0.000004581584,0.000091738,0.003302228,0.000003966478,0.000009392009,0.0001669293,0.00003661251,0.0003474553,0.9956425,0.00003115926,0.0003598202,0.000003600711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970669,0.0003153108,0.001743382,0.00002580236,0.00001117507,0.000013821,0.0001856707,0.00003733905,0.0006006379],"genre_scores_gemma":[0.9972357,0.0001684669,0.001633265,0.00001731858,0.000004873158,0.00001431621,0.0001507302,0.00002105191,0.0007542875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001949995,"threshold_uncertainty_score":0.006523371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0146284696042822,"score_gpt":0.2506276840313132,"score_spread":0.235999214427031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}