{"id":"W2942750287","doi":"10.1016/j.neuron.2019.03.046","title":"Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors","year":2019,"lang":"en","type":"article","venue":"Neuron","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Biotechnology and Biological Sciences Research Council; Fonds de Recherche du Québec - Santé; Comisión Nacional de Investigación Científica y Tecnológica; DanScatt; Canadian Institutes of Health Research; Islamic Development Bank; Natural Sciences and Engineering Research Council of Canada; Lundbeckfonden","keywords":"AMPA receptor; Allosteric regulation; Ionotropic effect; Ionotropic glutamate receptor; Chemistry; Glutamate receptor; Receptor; Agonist; Ion channel; Ligand-gated ion channel; Gating; Neuroscience; Biophysics; Cell biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002460805,0.0002201418,0.0002358975,0.0001051238,0.0003975042,0.001005583,0.0003817564,0.0004096118,0.002179572],"category_scores_gemma":[0.001099505,0.0003431804,0.0001637677,0.00008313828,0.0005837888,0.001116865,0.0004191633,0.0007673296,0.0005874391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004354585,"about_ca_system_score_gemma":0.0002689881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004588414,"about_ca_topic_score_gemma":0.0008862667,"domain_scores_codex":[0.9998525,0.00001534172,0.0000130175,0.0000382687,0.00004422413,0.00003661428],"domain_scores_gemma":[0.9996058,0.0001926428,0.00006876108,0.00003482565,0.0000441961,0.00005371347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000194641,0.00003285955,0.0007654064,0.00005628149,0.00001091469,0.0001151705,0.00009556818,0.0009590231,0.9903075,0.004489382,0.0002664221,0.002706944],"study_design_scores_gemma":[0.0000880714,0.0002276845,0.01077434,0.00003152988,0.00005412082,0.0003433339,0.0004647893,0.04331429,0.9358289,0.006087666,0.002708092,0.00007723242],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946815,0.0001770469,0.002904904,0.0002110159,0.00004479709,0.000006333487,0.00008840073,0.00004892593,0.001836962],"genre_scores_gemma":[0.9985722,0.0001472267,0.0007598663,0.00004634619,0.00001177068,0.000009051616,0.0000579501,0.00002722334,0.0003683429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002179572,"threshold_uncertainty_score":0.007291377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03509011504489629,"score_gpt":0.3238040287677236,"score_spread":0.2887139137228273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}