{"id":"W2942781492","doi":"10.1093/cercor/bhz085","title":"Accelerated Hyper-Maturation of Parvalbumin Circuits in the Absence of MeCP2","year":2019,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Rett Syndrome Research Trust; Scottish Rite Charitable Foundation of Canada; Nancy Lurie Marks Family Foundation","keywords":"MECP2; Perineuronal net; Parvalbumin; GABAergic; Neuroscience; Biology; Rett syndrome; Interneuron; Inhibitory postsynaptic potential; Phenotype; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006277572,0.0004319237,0.0001954385,0.0003076539,0.00009249105,0.0001939592,0.0001591714,0.000225112,0.0008536365],"category_scores_gemma":[0.0001127741,0.0001945592,0.000155502,0.0001018259,0.0002405745,0.0001367343,0.0002768082,0.0004961381,0.0001427582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002858426,"about_ca_system_score_gemma":0.0001945419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008927308,"about_ca_topic_score_gemma":0.001555851,"domain_scores_codex":[0.9998759,0.000009430998,0.00001060485,0.00003856938,0.00003938039,0.00002613503],"domain_scores_gemma":[0.9998785,0.00001173875,0.00005089555,0.000009111209,0.00001071334,0.00003896518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000255035,0.000004131949,0.0002737657,0.00001040805,0.000003251286,0.0001460156,0.000009194051,0.00002759132,0.9989682,0.00003833373,0.000009836065,0.0004837309],"study_design_scores_gemma":[0.00001093628,0.0001151594,0.03987748,0.000007196806,0.00002230556,0.002289137,0.00003310199,0.000698459,0.9554059,0.0001055355,0.001428711,0.000006150268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963153,0.0005648268,0.002033073,0.00003064788,0.00001417383,0.00001084896,0.0002337063,0.0001119462,0.0006855731],"genre_scores_gemma":[0.9959106,0.00038295,0.001585867,0.00002537832,0.000005320412,0.00002154072,0.0002551257,0.00003798755,0.001775095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008927308,"threshold_uncertainty_score":0.002855659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01446933418693985,"score_gpt":0.2359036526542601,"score_spread":0.2214343184673202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}