{"id":"W2942789806","doi":"10.1016/j.reprotox.2019.04.008","title":"Δ9-Tetrahydrocannabinol leads to endoplasmic reticulum stress and mitochondrial dysfunction in human BeWo trophoblasts","year":2019,"lang":"en","type":"article","venue":"Reproductive Toxicology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Children’s Health Research Institute; McMaster University; Lawson Health Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Endoplasmic reticulum; Unfolded protein response; Trophoblast; Mitochondrion; Endocrinology; Internal medicine; Biology; Cell biology; Placenta; Andrology; Fetus; Pregnancy; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003027068,0.0002591392,0.0005834165,0.0005415922,0.00008567526,0.00002778159,0.0001241213,0.0002433269,0.0004520392],"category_scores_gemma":[0.0004260141,0.0002442555,0.0000869428,0.0005260234,0.0002275057,0.0001032725,0.0001577843,0.0006073499,0.0001360953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003395446,"about_ca_system_score_gemma":0.0002010859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001766776,"about_ca_topic_score_gemma":0.0003042464,"domain_scores_codex":[0.9971136,0.0001724412,0.000392925,0.001297602,0.0003685814,0.000654874],"domain_scores_gemma":[0.9986727,0.00001968855,0.00008160276,0.0007442897,0.0002130519,0.0002687081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001249839,0.0004366993,0.0595982,0.0001637657,0.00004119833,0.00009652398,0.0006071776,0.00008846241,0.926156,0.0004201499,0.009889163,0.001252796],"study_design_scores_gemma":[0.005636365,0.006805506,0.413595,0.0001403722,0.00005601683,0.0003760686,0.0006384344,0.00005382699,0.5519844,0.0001960268,0.02008829,0.0004297344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822986,0.0001779725,0.00001235769,0.01258077,0.0009090284,0.002005982,0.00001204971,0.00005430588,0.001948971],"genre_scores_gemma":[0.9740029,0.00001964616,0.0001020324,0.0003092396,0.0007856532,0.0002250822,0.00001948421,0.00004534822,0.02449062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3741716,"threshold_uncertainty_score":0.9960449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102237328235504,"score_gpt":0.2835287843273715,"score_spread":0.2733050515038211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}